30results about How to "More complicated" patented technology

Methods and compositions for treating diabetes mellitus in a patient in need thereof are provided. The methods include administering to a patient a composition providing a gastrin / CCK receptor ligand, e.g., a gastrin, and / or an epidermal growth factor (EGF) receptor ligand, e.g., TGF-alpha, in an amount sufficient to effect differentiation of pancreatic islet precursor cells to mature insulin-secreting cells. The composition can be administered systemically or expressed in situ by cells transgenically supplemented with one or both of a gastrin / CCK receptor ligand gene, e.g., a preprogastrin peptide precursor gene and an EGF receptor ligand gene, e.g., a TGF-alpha gene. The methods also include transplanting into a patient cultured pancreatic islets in which mature insulin-secreting beta cells are proliferated by exposure to a gastrin / CCK receptor ligand and an EGF receptor ligand.

The present invention provides products, systems, and methods for the unique identification of individual drug dosage form units. The invention includes: random integrated optical identification marking of an individual drug unit; a lack of direct surface-to-surface contact between a marking instrument and the drug unit, i.e., deposition of a mark; drug unit image data based on the identification mark; a secondary product identifier associated with the individual drug unit; and comparing the marked drug unit to drug unit image data.

An improved automatic shutoff nozzle tip which is mounted on the downstream end of a nozzle body of an injection molding machine or the like who's purpose is to act as a passageway for molten plastic fluid allowing the fluid to flow in one direction when urged to open by the pressure created by the forward motion of the plasticizing screw of said molding machine and to close when said pressure is lower than the designed opening pressure. The nozzle, having an convex outwardly extended portion that mates up with a sprue bushing or mold having complimentary convex radii, said nozzle having a orifice on the distal end that mates with a complimentary orifice of said sprue bushing. A nozzle that has a means for attachment to a nozzle body or the like with a rear seat, poppet and spring or similar device who's poppet is normally in the closed position until pressure is applied urging the poppet to move in the downstream direction and providing for a passageway for molten plastic fluid.

A safety catheter for draining a given fluid includes a hollow stretch valve and a flexible, multi-lumen, balloon drainage catheter having a proximal catheter end, a balloon defining a balloon interior to be inflated with an inflation fluid, a drain lumen. and a balloon drainage port fluidically connecting the balloon interior to the drain lumen. The hollow stretch valve is shaped to permit the given fluid to pass therethrough and is positioned in the drain lumen to at least partially slide therein such that, in a steady state, the stretch valve prevents the inflation fluid from passing through the drainage port, and, in a stretched state when the proximal catheter end is stretched, the distal sliding portion slides within the drain lumen to permit the inflation fluid to pass through the drainage port and into the drain lumen.

The present disclosure relates, in general, to methods of treating or preventing hypoglycemia using a negative modulator antibody fragment that binds to the insulin receptor and modulates the action of insulin at the insulin receptor.

The present disclosure relates, in general, to methods of treating or preventing hypoglycemia using a negative modulator antibody fragment that binds to the insulin receptor and modulates the action of insulin at the insulin receptor.

A monitor used in an automobile includes an image sensing module, a visual field adjustor, and a display. The image sensing module includes a lens module and an image sensor secured on an emitting light path of the lens module. The visual field adjustor includes a prism made from transparent materials and movably installed in an incident light path of the lens module. When the automobile reverses, the image sensing module cooperates with the visual field adjustor to capture optical image signals, and the display uses the optical image signals to create an image and displays the image.

A safety catheter includes a flexible, multi-lumen shaft having an outer diameter, a distal tip, a proximal catheter end with a drain end and a proximal inflation end. The multi-lumen shaft defines a drain lumen, a distal hollow balloon portion, at least one inflation lumen, and a drainage port. A hollow stretch valve is coaxially disposed in the drainage lumen and has a radially self-expandable proximal section fixedly connected within the drain lumen by self-expansion, a flexible intermediate section longitudinally movable within the drain lumen, and a distal plug movably positioned in the drain lumen to prevent fluid from passing through the drainage port in a steady state and being slidably disposed within the drain lumen such that, in a stretched state when the proximal catheter end is stretched, the distal plug slides within the drain lumen to permit the inflation fluid to pass through the drainage port.

A method for manufacturing a safety catheter includes a flexible, multi-lumen shaft having a drain lumen draining fluid adjacent a distal tip of the shaft out a proximal drain end of the shaft and an inflation lumen. A hollow balloon portion has an inflation port fluidically connecting the inflation lumen to the balloon interior to inflate the balloon outwardly larger than a diameter of the shaft. The drain lumen is fluidically connected to the balloon interior by a drainage port. A hollow stretch valve in the drain lumen prevents fluid from passing through the drainage port in a steady state and permits fluid to pass therethrough in a stretched state when the shaft is stretched. Distal of a proximal end of the stretch valve, the shaft has a stretching extent that is relatively more stretchable than at least a portion of the shaft that is proximal of the stretching extent.

A safety catheter includes a flexible, multi-lumen shaft having an outer diameter, a distal tip, a proximal catheter end with a drain end and a proximal inflation end. The multi-lumen shaft defines a drain lumen, a distal hollow balloon portion, at least one inflation lumen, and a drainage port. A hollow stretch valve is coaxially disposed in the drainage lumen and has a radially self-expandable proximal section fixedly connected within the drain lumen by self-expansion, a flexible intermediate section longitudinally movable within the drain lumen, and a distal plug movably positioned in the drain lumen to prevent fluid from passing through the drainage port in a steady state and being slidably disposed within the drain lumen such that, in a stretched state when the proximal catheter end is stretched, the distal plug slides within the drain lumen to permit the inflation fluid to pass through the drainage port.

A safety catheter includes a flexible, multi-lumen shaft having an outer diameter, a distal tip, a proximal catheter end with a drain end and a proximal inflation end. The multi-lumen shaft defines a drain lumen, a distal hollow balloon portion, at least one inflation lumen, and a drainage port. A hollow stretch valve is coaxially disposed in the drainage lumen, has a fixed portion within the drainage lumen just proximal of an increased stretching portion, and prevents fluid from passing through the drainage port in a steady state. The stretch valve has a sliding portion slidably disposed within the drainage lumen such that, in a stretched state when the proximal catheter end is stretched, the sliding portion slides within the drainage lumen to permit fluid to pass through the balloon drainage port and / or inner wall of the catheter.