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A kind of curcumin powder mist inhalation preparation and preparation method thereof

An inhalation preparation, the technology of curcumin, which is applied in the field of medicine, can solve the problems of unreported research on curcumin powder mist inhalation preparations, and achieve the effects of rich blood flow, rapid drug absorption, and improved bioavailability

Active Publication Date: 2022-07-29
天津市医药科学研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But, the research about curcumin powder mist inhalation preparation has not been reported at present

Method used

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  • A kind of curcumin powder mist inhalation preparation and preparation method thereof
  • A kind of curcumin powder mist inhalation preparation and preparation method thereof
  • A kind of curcumin powder mist inhalation preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The curcumin powder mist inhalation preparation includes the following raw materials by weight: curcumin 1g, glycerol monostearate 10g, PEG-25 stearate 20g, poloxamer 18810g, Tween-8020g, trehalose 40g, 400 inhaled lactose 70g and water 2000g.

[0052] The preparation method specifically includes the following steps:

[0053] (1) take by weighing each raw material by the weight of above-mentioned curcumin powder mist inhalation preparation;

[0054] (2) curcumin, glyceryl monostearate and PEG-25 stearate are added in 500g dehydrated alcohol, placed on a constant temperature magnetic stirrer, at a temperature of 78 ° C, a constant temperature magnetic force at a speed of 900 rpm Stir for 2min to dissolve, obtain an organic phase, for subsequent use;

[0055] (3) Poloxamer 188 and Tween-80 are added to water, placed on a constant temperature magnetic stirrer, and at a temperature of 75 ° C, a speed of 900 rpm is a constant temperature magnetic stirring 5min to dissolve...

Embodiment 2

[0061] The curcumin powder mist inhalation preparation includes the following raw materials by weight: 1 g of curcumin, 9 g of glyceryl behenate, 19 g of PEG-36 stearate, 1889 g of poloxamer, 19 g of Tween-8019 g, 36 g of trehalose, 40064g and water 1800g.

[0062] The preparation method specifically includes the following steps:

[0063] (1) take by weighing each raw material by the weight of above-mentioned curcumin powder mist inhalation preparation;

[0064] (2) curcumin, glyceryl behenate and PEG-36 stearate are added in 440g absolute ethanol, placed on the constant temperature magnetic stirrer, at a temperature of 75 ℃, speed is constant temperature magnetic stirring under the condition of 420rpm 1min to dissolve, obtain organic phase, standby;

[0065] (3) Poloxamer 188 and Tween-80 are added to water, placed on a constant temperature magnetic stirrer, and at a temperature of 70 ° C, a speed of 420 rpm is a constant temperature magnetic stirring 3min to dissolve, to ...

Embodiment 3

[0071] Curcumin powder mist inhalation preparation, including the following raw materials: curcumin 1.25g, glyceryl distearate 11g, PEG-40 stearate 22g, poloxamer 18811g, Tween-8022g, mannitol 44g , 40079g and water 2200g.

[0072] The preparation method specifically includes the following steps:

[0073] (1) take by weighing each raw material by the weight of above-mentioned curcumin powder mist inhalation preparation;

[0074] (2) Curcumin, glyceryl distearate and PEG-40 stearate are added in 610g absolute ethanol, placed on a constant temperature magnetic stirrer, at a temperature of 80 ° C, a constant temperature magnetic force at a speed of 900 rpm Stir for 3min to dissolve, obtain an organic phase, for subsequent use;

[0075] (3) Poloxamer 188 and Tween-80 are added to water, placed on a constant-temperature magnetic stirrer, and at a temperature of 78° C., a speed of 900 rpm is followed by constant-temperature magnetic stirring for 5min to dissolve, to obtain an aq...

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Abstract

The invention discloses a curcumin powder mist inhalation preparation, comprising the following raw materials: curcumin, lipid material, polyoxyethylene stearate, poloxamer 188, Tween-80, freeze-drying protective agent, lactose and water; the preparation method is: (1) weighing each raw material; (2) adding curcumin, lipid material and polyoxyethylene stearate in absolute ethanol to dissolve to obtain an organic phase; (3) adding polox Sharm 188 and Tween-80 are added in water and dissolved to obtain an aqueous phase; (4) organic phase is added to the aqueous phase, and dehydrated alcohol is removed; (5) is added to cold water, and the cold water bath is continuously stirred and filtered; (6) added Freeze-drying protective agent, freeze-drying; (7) adding lactose, sieving, and obtaining. The present invention does not use propellants and solvents, and relies on airflow to atomize the drug powder, thereby enabling the drug powder to be delivered to the lungs, and has the characteristics of convenient application, rapid absorption and targeted positioning.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a powder mist inhalation preparation, more particularly to a curcumin powder mist inhalation preparation and a preparation method thereof. Background technique [0002] Curcumin is a chemical component extracted from the rhizomes of some plants in the Zingiberaceae and Araceae. Among them, turmeric contains about 3%-6%, which is a very rare pigment with diketones in the plant kingdom and is a diketone. compound. Its main bioactive components are curcumin and volatile oil. The former has the functions of lowering blood lipids, anticoagulation, antioxidation, choleresis, and anticancer. The latter mainly plays the role of anti-inflammatory, antibacterial and antitussive. Curcuminoids exert their anticancer effects by inducing the differentiation of malignant tumor cells, inducing tumor cell apoptosis and inhibiting tumor growth in various stages. They have a wide range of clinica...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/72A61K9/14A61K47/14A61K47/12A61K47/26A61K47/36A61K47/10A61K31/12A61P11/00
CPCA61K9/0075A61K9/145A61K9/146A61K31/12A61P11/00
Inventor 李楠李旭
Owner 天津市医药科学研究所
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