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XAB2 protein as marker for prognosis and/or prediction of platinum drug resistance of ovarian cancer

A technology for ovarian cancer and protein, applied in the field of biomedicine, can solve problems such as relationships that have not been reported in the literature

Pending Publication Date: 2020-10-16
张瑜
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] But so far, the relationship between XAB2 protein and the prognosis and platinum resistance of ovarian cancer, especially high-grade serous ovarian cancer, has not been reported in the literature.

Method used

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  • XAB2 protein as marker for prognosis and/or prediction of platinum drug resistance of ovarian cancer
  • XAB2 protein as marker for prognosis and/or prediction of platinum drug resistance of ovarian cancer

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Embodiment 1

[0029] 1. Test method:

[0030] We collected archival wax blocks of surgical specimens from 56 patients with high-grade serous ovarian cancer from 2014 to 2018, and the specimens were serially sectioned into paraffin sections. After xylene dewaxing and gradient ethanol hydration, the expression of the target protein was detected by the biotin method. The specific method is as follows:

[0031] (1) Paraffin sections of ovarian cancer tumor tissues were baked at 65°C, dewaxed with xylene, and hydrated with graded ethanol.

[0032] (2) Antigen retrieval of slices with EDTA antigen retrieval solution (pH=9.0), 3% H 2 o 2 Inactivation of endogenous peroxidase followed by blocking with goat serum.

[0033] (3) Incubate XAB2 primary antibody at 4°C overnight in a wet box.

[0034] (4) The slices were washed three times with PBS solution for immunohistochemistry, and biotin-labeled goat anti-mouse / rabbit IgG polymer (reagent 3) was added dropwise, incubated at room temperature for...

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Abstract

The invention belongs to the technical field of biomedicine, and particularly discloses application of XAB2 protein as a marker for prognosis and / or prediction of platinum drug resistance of ovarian cancer. The invention discloses a protein-XAB2 closely related to generation of platinum drug resistance of ovarian cancer cells; XAB2 protein expression in ovarian cancer tissues is detected through an immunohistochemical method, ovarian cancer prognosis is judged, and / or platinum drug resistance is predicted. The expression level of the XAB2 protein in ovarian cancer is related to the survival rate of patients, the prognosis of patients with high expression of the XAB2 protein is poor, and the total survival rate and the progression-free survival rate are both reduced. The expression level ofthe XAB2 protein is not only related to prognosis of a patient, but also high in expression level of the XAB2 protein is related to platinum drug resistance of an ovarian cancer patient, and the riskof platinum drug resistance of the patient with high expression level of the XAB2 protein is increased. The XAB2 protein is used as a biomarker for prognosis of ovarian cancer and / or prediction of platinum drug resistance, and has broad application prospects and huge potential social benefits.

Description

technical field [0001] The present invention relates to the field of biomedical technology, in particular to XAB2 protein as a marker for prognosis and / or prediction of platinum drug resistance in ovarian cancer, especially XAB2 protein as a marker for prognosis and / or prediction of platinum drug resistance in high-grade serous ovarian cancer, As well as reagents and kits for detecting the marker. Background technique [0002] Ovarian cancer (Ovarian Cancer) is the gynecological malignancy with the worst prognosis. Its main pathological type is high-grade serous ovarian cancer (HGSOC), and its five-year survival rate is only 47%. The current standard treatment options for ovarian cancer include cytoreductive surgery and platinum-based combination chemotherapy. Even after ideal cytoreductive surgery and adequate chemotherapy, 70% of patients will still have recurrence and metastasis. [0003] Platinum resistance: Ovarian cancer patients who are sensitive to platinum drugs i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G01N33/68
CPCG01N33/57449G01N33/57484G01N33/68G01N2800/54
Inventor 张瑜吴丽莎杨斯宇杨文青
Owner 张瑜
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