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Application of dexamethasone to preparation of drugs for preventing or alleviating jellyfish stings

A technology of dexamethasone and medicine, applied in the field of application of dexamethasone or its derivatives in the preparation of medicines for preventing or alleviating jellyfish stings

Inactive Publication Date: 2020-10-20
THE NAVAL MEDICAL UNIV OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preventive effect of dexamethasone on female stings has not been reported in the literature

Method used

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  • Application of dexamethasone to preparation of drugs for preventing or alleviating jellyfish stings
  • Application of dexamethasone to preparation of drugs for preventing or alleviating jellyfish stings
  • Application of dexamethasone to preparation of drugs for preventing or alleviating jellyfish stings

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Dexamethasone can improve the survival and mortality of mice after being stung

[0027] 1. Experimental method

[0028] Male mice aged 7 weeks in ICR were selected for the experiment, and the experimental mice were divided into four groups: the experimental group DXMS-TE group (n=12), the positive control group PBS-TE group (n=12), the negative control group DXMS -PBS group (n=12), blank control group PBS-PBS group (n=12).

[0029] After the weight of the mouse was weighed and recorded, the first corresponding reagent of each group was injected intravenously according to the metering 0.5ml / 10mg, and the second corresponding reagent of the grouping was injected again according to the metering 0.5ml / 10mg 10min later. Each mouse was injected twice in total successively, two mice were injected in each group sequentially, put into two perforated lunch boxes containing 20ml sea water respectively, and the injection time was recorded.

[0030] The four groups shou...

Embodiment 2

[0035] Example 2: Dexamethasone can improve the changes of hematological indicators in mice

[0036] 1. Experimental method:

[0037] In order to verify the effect of dexamethasone on the blood indexes of multiple organs after the sting, blood biochemical analysis was performed on the blood of the mice after the sting.

[0038] Male mice aged 7 weeks in ICR were selected for the experiment, and the experimental mice were divided into four groups: the experimental group DXMS-TE group (n=6), the positive control group PBS-TE group (n=6), the negative control group DXMS -PBS group (n=6), blank control group PBS-PBS group (n=6). After 8 hours of mouse reagent injection in each group, blood was taken from the orbit and placed in a centrifuge tube soaked in 0.5% heparin sodium solution, centrifuged at 3000r for 10 minutes, the supernatant was taken, and the following indicators were immediately determined using a SIEMENS kit:

[0039] Related indicators of liver and kidney functio...

Embodiment 3

[0045] Example 3: Dexamethasone can significantly improve the increase of inflammatory indicators in multiple organs in mice

[0046] 1. Experimental method:

[0047] Experimental groups were divided into four major groups: DXMS-TE group (n=4), DJES group (n=4), negative control group (n=4) and blank control group (n=4). The kidney, liver, heart and skin samples of each group of mice were taken 8 hours after reagent injection, and then the total RNA was extracted, rRNA was enriched by OligodT, strand-specific cDNA library was constructed, and sequenced by Illumina HiSeq4000 sequencer, etc.; The analysis work after machine data includes FastQC software to evaluate the sequencing quality, Hisat2 software to compare the reference genome, StringTie software to estimate transcript abundance, R software Ballgown to calculate FPKM and screen differential genes, etc.; further PCA analysis, correlation analysis, differential gene analysis, etc. Cluster analysis, GO functional annotati...

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Abstract

The invention relates to the technical field of medicine and provides an application of dexamethasone or derivatives thereof to preparation of drugs for preventing or alleviating jellyfish stings. Experiments show that after mice are treated 10 min before being stung, the survival time of the mice can be significantly prolonged, the death rate of the mice is reduced, and the change degrees of a cardiac function index, a hepatic function index and a renal function index in mice caused by physaliatoxin are significantly reduced; and through transcriptome analysis of the mice, it is found that after the mice are treated 10 min before being stung, the combined injury of multiple organs can be significantly improved, the degree of inflammation between multiple organs is reduced, and a new theoretical basis is provided for preventing the jellyfish stings through the dexamethasone or the derivatives thereof. The dexamethasone is mature anti-inflammatory agent and immunosuppressant, and the trade name of the dexamethasone is a dexamethasone acetate tablet and the like, so that the dexamethasone is definite in pharmacological action and small in toxic and side effects, the drug safety has been clinically approved, and clinical transformation of new indications of the dexamethasone provided by the invention can be quickly realized.

Description

technical field [0001] The invention belongs to the field of biomedicine and provides a new application of dexamethasone, in particular to the application of dexamethasone or its derivatives in the preparation of medicines for preventing or alleviating jellyfish stings. Background technique [0002] Jellyfish (Jelly fish) is one of the oldest and mysterious creatures in the world. It existed on the earth about 650 million years ago and is distributed in almost all sea areas. In terms of quantity, the number of jellyfish has exploded in recent decades, which not only leads to the destruction of marine ecosystems, but also causes catastrophic damage to marine fisheries, and the number of jellyfish stings continues to increase, and tens of thousands of people are injured every year , becomes a very difficult problem. [0003] Since the 1940s, Pubmed has paid attention to and gradually reported Portuguese man-of-war, Irukandji jellyfish, sea wasp jellyfish (Chironex fleckeri), ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61P39/02A61P29/00
CPCA61K31/573A61P29/00A61P39/02
Inventor 肖良叶瑞威梁洪昱张晶刘文文李俊刘青家常亮
Owner THE NAVAL MEDICAL UNIV OF PLA
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