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7-substituted sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of liver cancer

A kind of technology of propyl sulfoimidoyl compound, applied in new sulfonimyl purinone derivatives, ogaL., Liebe field

Pending Publication Date: 2020-10-20
F HOFFMANN LA ROCHE & CO AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, to date, no TLR7 agonist has been used systemically to treat cancer

Method used

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  • 7-substituted sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of liver cancer
  • 7-substituted sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of liver cancer
  • 7-substituted sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of liver cancer

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Embodiment Construction

[0036] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In addition, the following definitions are set forth to illustrate and define the meaning and scope of various terms used to describe the present invention.

[0037] The term "C 1-6 "Alkyl" means a saturated linear or branched chain alkyl group containing 1 to 6, especially 1 to 4 carbon atoms, for example methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl , tert-butyl, etc. Special "C 1-6 "Alkyl" groups are methyl, ethyl and n-propyl.

[0038] The term "C 1-6 Alkoxy" represents the formula C 1-6 A group of alkyl-O-. C 1-6 Examples of alkoxy include, but are not limited to, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, and tert-butoxy. Special "C 1-6 "Alkoxy" is methoxy, ethoxy and isopropoxy. More particularly C 1-6 Alkoxy is ethoxy.

[0039] The terms "halo...

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Abstract

The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, for (use in) the treatment and / or prophylaxis of liver cancer.

Description

[0001] The present invention relates to novel sulfoiminoylpurinone derivatives, which have Toll-like receptor agonistic activity in vivo, and are used (for) in the treatment and / or prevention of liver cancer. Background technique [0002] Liver cancer is the fifth most common cancer. About 75,000 cases are diagnosed each year, and about 700,000 people die from the disease, making it the third leading cause of cancer death in the world (Ferlay et al., Int. J. Cancer 127:2893-2917 (2010)). In the United States, the incidence of primary liver cancer has been rising, and despite some advances in detection and treatment of localized disease, the five-year survival rate for advanced liver cancer remains well below 10% (American-Cancer-Society. 2012. Cancer Facts & Figures 2012. Atlanta: American Cancer Society). [0003] Established treatments for liver cancer include surgical removal of the part of the liver containing the tumor (partial hepatectomy), liver transplantation, transc...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61P35/00
CPCA61K31/522A61P35/00A61K45/06A61K39/39A61K2300/00A61K39/395C07D473/24C07K16/2818A61K2039/505
Inventor T·珀施因格C·里斯沈宏贠红英S·霍弗斯C·哈格
Owner F HOFFMANN LA ROCHE & CO AG
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