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Hepatitis b virus (HBV) vaccines and uses thereof

A polynucleotide, sequence technology, applied in another general aspect, can solve problems such as the unproven success of therapeutic vaccination

Pending Publication Date: 2020-10-27
杨森科学爱尔兰无限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many strategies have been investigated, but the success of therapeutic vaccination has not yet been proven

Method used

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  • Hepatitis b virus (HBV) vaccines and uses thereof
  • Hepatitis b virus (HBV) vaccines and uses thereof
  • Hepatitis b virus (HBV) vaccines and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0242] Embodiment 1 includes an isolated or non-naturally occurring nucleic acid molecule comprising a polynucleotide sequence encoding a truncated HBV core antigen consisting of an amino acid sequence, wherein Said amino acid sequence is at least 90% identical to SEQ ID NO:2 or SEQ ID NO:14, preferably 100% identical to SEQ ID NO:2 or SEQ ID NO:14; preferably, said truncated HBV core antigen can be Inducing an immune response against at least two HBV genotypes in a mammal; more preferably, the truncated HBV core antigen is capable of inducing a T cell response against at least HBV genotypes B, C and D in a mammal; further preferably Preferably, the truncated HBV core antigen is capable of inducing a CD8 T cell response against at least HBV genotypes A, B, C and D in a human subject; and most preferably, the truncated HBV core antigen encodes The sequence comprises a polynucleotide which is at least 90% identical to SEQ ID NO: 1 or SEQ ID NO: 15, for example 90%, 91%, 92%, 93%...

Embodiment approach 2

[0243] Embodiment 2 includes the non-naturally occurring nucleic acid molecule of embodiment 1, wherein the truncated HBV core antigen consists of the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:14.

Embodiment approach 3

[0244] Embodiment 3 includes the non-naturally occurring nucleic acid molecule of Embodiment 1 or Embodiment 2, further comprising a polynucleotide sequence encoding a signal sequence operably linked to an HBV polymerase antigen.

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Abstract

Polynucleotides encoding hepatitis B virus (HBV) core antigen and polymerase antigen, and related combinations are described. Also described are vectors, such as DNA plasmids or viral vectors, expressing the HBV core and polymerase antigens, and immunogenic compositions containing the expression vectors. Methods of inducing an immune response against HBV or treating a HBV-induced disease, particularly in individuals having chronic HBV infection, using the immunogenic compositions are also described.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to International Patent Application No. PCT / IB2017 / 058142, filed December 19, 2017, and U.S. Provisional Patent Application No. 62 / 607,426, filed December 19, 2017, the disclosures of which are incorporated herein by reference in their entirety. [0003] References to Sequence Listings Submitted Electronically [0004] This application contains a sequence listing, which is a sequence listing in ASCII format electronically submitted through EFS-Web, the file name is "688097-403 Sequence Listing", the date of generation is December 10, 2018, and the size is 46.6KB. The sequence listing submitted via EFS-Web is part of the specification and is hereby incorporated by reference in its entirety. Background technique [0005] Hepatitis B virus (HBV) is a 3.2-kb small hepadnavirus encoding four open reading frames and seven proteins. About 2 billion people are infected with HBV, and about 24...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/29A61K39/295A61P31/20
CPCA61K39/29A61K39/295A61K2039/53C12N2730/10134A61P31/20A61K39/292C07K14/005
Inventor D·博登H·霍顿J-M·E·F·M·尼芙斯S·罗伊D·德普特尔
Owner 杨森科学爱尔兰无限公司