CircRNA related to malignant melanoma and application of circRNA

Abstract

The invention discloses circRNA related to malignant melanoma and application of the circRNA, and belongs to the technical field of biological medicine. The circRNA in the application is circRNA _ 0012891, and it is found for the first time that the expression level of circRNA _ 0012891 is related to melanoma metastasis. The invention provides a circRNA diagnostic marker which is circRNA _ 0012891, and also provides a product which can be used for diagnosing whether melanoma metastasis exists or not, and improving the survival rate and the life quality of melanoma patients through advanced detection.

Description

technical field [0001] The embodiment of the present invention relates to the field of biomedical technology, in particular to a circRNA related to malignant melanoma and its application. Background technique [0002] Melanoma, also called malignant melanoma (MM), accounts for about 1% to 3% of all malignant tumors. Cutaneous melanoma (CMM) is an aggressive tumor derived from the malignant transformation of epidermal melanocytes. It is the malignant tumor with the fastest progression and the poorest prognosis among all skin tumors, with blood supply or lymph node metastasis in the later stage. Its onset is insidious, and it is prone to early metastasis. Most of the patients who seek medical treatment are in the middle and late stages, and the mortality rate within 5 years of metastasis is high. In recent years, the morbidity and mortality of MM have shown an obvious upward trend. The American Cancer Society (ACS) reported in 2017 that, except for the morbidity and mortality...

AI Technical Summary

Problems solved by technology

[0005] At present, circRNA (circRNA0012891) has not been applied to distinguish MM metastasis, and its clinical diagnostic efficacy in the field of MM has not been determined

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