Preparation method of hydroxyapatite microspheres

A technology of hydroxyapatite and microspheres, which is applied in the field of preparation of hydroxyapatite microspheres, can solve the problems of complex preparation process, uneven particle size distribution of microspheres, low yield, etc., and achieve simple preparation process and high pore size. Flexible and controllable, uniform hole distribution effect

Inactive Publication Date: 2020-11-06
无锡迈科为生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are many problems in the current method of preparing hydroxyapatite microspheres, such as: uneven particle size distribution of microspheres, low yield and complicated preparation process, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The invention discloses a preparation method of hydroxyapatite microspheres, comprising the following steps:

[0030] (1) Introducing a calcium source and a phosphorus source in a solvent to form a calcium phosphate suspension;

[0031] (2) adding the polymer seeds to the dispersion system containing ethanol / water to form a uniformly dispersed seed suspension, wherein the solid content of the polymer seeds is 5-9 g / L;

[0032] (3) Add the calcium phosphate suspension into the seed suspension, stir evenly, and gradually add an emulsifier and an initiator, wherein the emulsifier and the initiator satisfy the following proportional relationship: W=W0(V / 3.5~ 4.5), wherein, W is the quality of emulsifying agent, W0 is the quality of initiator, and V is the volume of polymer seed, and the dropping speed of described calcium phosphate suspension is 0.2~3ml / min, and the dropping speed of described emulsifying agent 1-3ml / min, the drip rate of the initiator is 2-5ml / min, keep t...

Embodiment 2

[0035] (1) Introducing a calcium source and a phosphorus source in a solvent to form a calcium phosphate suspension;

[0036] (2) adding the polymer seed to the dispersion system containing ethanol / water to form a uniformly dispersed seed suspension, wherein the solid content of the polymer seed is 7g / L;

[0037] (3) Add the calcium phosphate suspension into the seed suspension, stir evenly, and gradually add an emulsifier and an initiator, wherein the emulsifier and the initiator satisfy the following proportional relationship: W=W0(V / 3.5~ 4.5), wherein, W is the quality of emulsifying agent, W Be the quality of initiator, V is the volume of polymer seed, and the rate of addition of described calcium phosphate suspension is 1.6ml / min, and the rate of addition of described emulsifier is 2ml / min, the titration rate of the initiator is 3.5ml / min, keep the temperature at 70°C for constant temperature reaction for 150 minutes, wash and dry to form polymer-hydroxyapatite microspher...

Embodiment 3

[0040] The invention discloses a preparation method of hydroxyapatite microspheres, comprising the following steps:

[0041] (1) Add calcium source and phosphorus source to 100ml water to form Ca 4 (PO 4 ) 2 O suspension;

[0042] (2) Select polystyrene seeds (particle size 10um, CV=3%) and add ethanol and water in the ethanol / water dispersion system with a volume ratio of 1:1 to form a uniformly dispersed seed suspension, wherein the polystyrene seeds The solid content is 5g / L;

[0043] (3) the Ca 4 (PO 4 ) 2 Add the O suspension into the seed suspension, stir evenly, and gradually add sodium lauryl sulfate and potassium persulfate, wherein the added sodium lauryl sulfate and potassium persulfate satisfy the following proportional relationship: W=W 0 (V / 3.5~4.5), wherein, W is the quality of emulsifier, W 0 Is the quality of the initiator, V is the volume of the polymer seed, wherein, the above Ca 4 (PO 4 ) 2The rate of addition of the O suspension is 0.2ml / min, th...

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PUM

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Abstract

The invention discloses a preparation method of hydroxyapatite microspheres. The preparation method comprises the following steps of: (1) introducing a calcium source and a phosphorus source into a solvent to form a calcium phosphate suspension; (2) adding polymer seeds into a dispersion system containing ethanol / water to form a uniformly dispersed seed suspension, the solid content of the polymerseeds being 5-9 g / L; (3) adding the calcium phosphate suspension into the seed suspension, performing uniform stirring, and gradually adding an emulsifier and an initiator, the emulsifier and the initiator satisfying the following proportional relationship: W=W0 (V / 3.5-4.5); and (4) calcining polymer-hydroxyapatite microspheres at a high temperature to obtain the porous hydroxyapatite microspheres. The prepared porous hydroxyapatite microspheres are controllable in particle size, uniform in particle size and controllable in pore diameter.

Description

technical field [0001] The invention relates to the technical field of hydroxyapatite microspheres, in particular to a preparation method of hydroxyapatite microspheres. Background technique [0002] As an ideal bone repair material, hydroxyapatite mainly exists in hard tissues such as human bones and teeth. It is an important inorganic component and has the advantages of good osteoconductivity, bioactivity and biocompatibility. Porous hydroxyapatite microspheres have been widely used in tissue engineering and drug separation due to their low relative density, high specific surface area, and light weight. [0003] At present, the methods for preparing hydroxyapatite microspheres mainly include microemulsion method and spray drying method. Chinese patent (Application No. 200910104114.x) discloses a method for preparing nano-hydroxyapatite / polylactic acid composite microspheres. Nano-hydroxyapatite microspheres are prepared by ultrasonic blending and compounding process and e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32C07K1/14
CPCC01B25/32C01P2004/34C01P2004/61C01P2006/17C07K1/14
Inventor 阳承利
Owner 无锡迈科为生物科技有限公司
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