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Method for predicting Parkinson's disease with cognitive impairment based on GDNF (glial cell line-derived neurotrophic factor)

A technology for cognitive dysfunction and Parkinson's disease, applied in diagnostic recording/measurement, medical science, sensors, etc., can solve problems such as unclear GDNF precursor

Inactive Publication Date: 2020-11-10
XUZHOU MEDICAL UNIV
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Problems solved by technology

In the process of transcription and translation, GDNF gene will produce two precursor proteins, α-pro-GDNF and β-pro-GDNF, which can be secreted to the outside of the cell to play a role like mature GDNF, but there is no information about GDNF. The distribution of precursors in neurodegenerative diseases and the relationship between serum GDNF precursors and PDCI have been reported, and it is not clear how GDNF precursors regulate the changes in GDNF content

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  • Method for predicting Parkinson's disease with cognitive impairment based on GDNF (glial cell line-derived neurotrophic factor)
  • Method for predicting Parkinson's disease with cognitive impairment based on GDNF (glial cell line-derived neurotrophic factor)
  • Method for predicting Parkinson's disease with cognitive impairment based on GDNF (glial cell line-derived neurotrophic factor)

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[0023] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention.

[0024]see Figure 1-9 , an embodiment provided by the present invention: a method for predicting cognitive dysfunction in Parkinson's disease based on GDNF, including test subjects, materials and evaluation methods, test subjects and materials including test subjects screening and specimen collection, test subjects Patients were screened to collect outpatients and inpatients with primary PD in the Affiliated Hospital of Xuzhou Medical University from April 2018 to August 2019. Two experienced neurologists conducted detailed demographic statistics, medical history, course of disease, and The collection and evaluation of data such as motor symptoms and treatment condit...

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Abstract

The invention discloses a method for predicting a Parkinson's disease with cognitive impairment based on GDNF (glial cell line-derived neurotrophic factor). 53 cases of patients suffering from the Parkinson's disease are introduced, and according to a simple mental state scale, a Montreal cognitive assessment scale, a clinical dementia assessment scale and other cognitive psychological function scales, scores are divided into a Parkinson's disease accompanied cognitive impairment group (27 cases) and a Parkinson's disease unaccompanied cognitive impairment group (26 cases); and 26 healthy oldpeople are selected as a healthy control group, and the levels of serum GDNF and precursors thereof are detected by an Elisa method, and the relationship between the levels and the cognitive psychological function scores is analyzed.

Description

technical field [0001] The invention relates to the field of products related to Parkinson's disease, in particular to a method for predicting cognitive dysfunction of Parkinson's disease based on GDNF. Background technique [0002] Parkinson's disease (Parkinson's disease, PD) is the second largest neurodegenerative disease, and the prevalence rate is about 2%-3% in people over 65 years old. The degeneration and loss of dopaminergic neurons (Dopaminergic neuron, DN) in the substantia nigra lead to the lack of dopamine (DA) in the striatum and the formation of inclusion bodies characterized by α-synuclein in the substantia nigra DN are the main causes of Parkinson's disease. neuropathic features. The course of PD is accompanied by many non-motor symptoms (NMS), which aggravate the disability of the patient and cause great physical and psychological trauma. In recent years, NMS of PD has received more and more attention, especially cognitive impairment (Cognitive impairment...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
CPCA61B5/4088
Inventor 史明语高殿帅马成成吴姣秦登利陈刚
Owner XUZHOU MEDICAL UNIV
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