Glucagon like peptide 1 (glp-1) fusion peptide coupled cyclic peptide tyrosine tyrosine conjugates and uses thereof

A technology of GLP-1 and glucagon, applied in the field of cyclic peptide tyrosine-tyrosine conjugates, which can solve the problems of impracticality and short half-life
CN112004822APending Publication Date: 2020-11-27JANSSEN PHARMA NV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JANSSEN PHARMA NV
Publication Date
2020-11-27

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Abstract

The present invention comprises conjugates comprising a glucagon-like peptide 1 (GLP-1) fusion peptide coupled to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.
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Description

[0001] Cross References to Related Applications

[0002] This application claims priority to PCT Application PCT / US2018 / 029284, filed April 25, 2018, and US Provisional Application 62 / 662,313, filed April 25, 2018. The entirety of each publication is incorporated herein by reference. technical field

[0003] The present invention generally relates to novel glucagon-like peptide 1 (GLP-1) fusion peptide coupled cyclic peptide tyrosine-tyrosine (PYY) conjugates, which are neuropeptide Y2 receptors and GLP-1 Modulators of receptors. The invention also relates to pharmaceutical compositions and methods of their use. The novel GLP-1 fusion peptide-coupled cyclic PYY conjugate can be used to prevent, treat or improve diseases and disorders such as obesity, type 2 diabetes, metabolic syndrome, insulin resistance and dyslipidemia.

[0004] Reference Sequence Listing Submitted Electronically

[0005] This application contains a Sequence Listing submitted electronically via EFS-W...

Claims

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