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Fructus gardeniae-poria cocos extract, extraction method and application of fructus gardeniae-poria cocos extract to preparation of medicine for treating hyperuricemia

A technology of Poria cocos extract and hyperuricemia, which is applied in the field of medicine and/or health care products, can solve the problem that there is no gardenia-Poria cocos extract, and can reduce the level of oxidative stress damage and inflammation, without toxic side effects, Improve the effect of hyperuricemia

Inactive Publication Date: 2020-12-18
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report on the treatment of hyperuricemia and its mechanism by Gardenia-Poria cocos extract

Method used

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  • Fructus gardeniae-poria cocos extract, extraction method and application of fructus gardeniae-poria cocos extract to preparation of medicine for treating hyperuricemia
  • Fructus gardeniae-poria cocos extract, extraction method and application of fructus gardeniae-poria cocos extract to preparation of medicine for treating hyperuricemia
  • Fructus gardeniae-poria cocos extract, extraction method and application of fructus gardeniae-poria cocos extract to preparation of medicine for treating hyperuricemia

Examples

Experimental program
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Effect test

Embodiment 1

[0018] A Gardenia-Poria extract, which is obtained by the following extraction method, specifically: 500g of dried Gardenia and 500g of Poria are respectively crushed and mixed, then soaked in 15 L of distilled water for 0.5h, and decocted at 85°C for 1h , filtered, and the filtrate was collected. Add 10L of distilled water to the filter residue and cook again at 85°C for 0.5h, filter again, combine the two filtrates, concentrate under reduced pressure, and freeze-dry in a freeze dryer to obtain the gardenia-poria water extract, about 110 g.

Embodiment 2

[0020] A Gardenia-Poria extract, which is obtained by the following extraction method, specifically: 500g of dried Gardenia and 500g of Poria are respectively crushed and mixed, then soaked in 12 L of distilled water for 0.5h, and decocted at 85°C for 1h , filtered, and the filtrate was collected. Add 12 L of distilled water to the filter residue and cook again at 85°C for 1 hour, filter again, combine the two filtrates, concentrate under reduced pressure, and freeze-dry in a freeze dryer to obtain the gardenia-poria water extract, about 106 g.

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Abstract

The invention relates to an extraction method of a fructus gardeniae-poria cocos extract. The method comprises the following steps: mixing poria cocos and fructus gardeniae, adding distilled water forsoaking, performing decocting and filtering, and performing decompression concentration and freeze-drying on filtrate to obtain the fructus gardeniae-poria cocos extract. The fructus gardeniae-poriacocos extract is extracted from fructus gardeniae and poria cocos, and the possible hyperuricemia lowering mechanism of a rat is analyzed by measuring the influence of the fructus gardeniae-poria cocos extract on various biochemical indexes of the rat with hyperuricemia and the influence of the fructus gardeniae-poria cocos extract on in-vivo oxidative stress factors and inflammatory factors of the rat with hyperuricemia. Experimental results prove that the fructus gardeniae-poria cocos extract can effectively treat hyperuricemia of rats by reducing oxidative stress injury and inflammation level, and has no toxic or side effect. Therefore, the fructus gardeniae-poria cocos extract can be used for preparing a medicine for treating hyperuricemia.

Description

technical field [0001] The invention belongs to the technical field of medicine and / or health care products, and in particular relates to a gardenia-Poria cocos extract, an extraction method and its application in the preparation of medicines for treating hyperuricemia. Background technique [0002] Hyperuricemia (HUA) is the biochemical basis of gout, mainly a metabolic disease caused by decreased excretion or increased production of uric acid. In recent years, the number of patients with hyperuricemia has increased significantly, and the incidence rate has increased year by year, showing a younger trend. High uric acid can cause oxidative stress, which can directly or indirectly cause renal inflammatory damage through various pathways. At the same time, hyperuricemia is also a risk factor for cardiovascular and cerebrovascular diseases. Uric acid induces inflammatory responses by promoting oxidative stress in the body, thereby participating in the formation of atheroscler...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61K36/076A61P19/06
CPCA61K36/076A61K36/744A61K2236/331A61K2236/39A61K2236/51A61P19/06A61K2300/00
Inventor 康文艺王金梅张岩刘绪强蒋圣军赵青春邵文静
Owner HENAN UNIVERSITY
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