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Application of isoglycyrrhizic acid to preparation of drugs used for treating hyperuricemia

A technology of hyperuricemia and isoglycyrrhizic acid, applied in the field of medicine, can solve the problems such as the use that has not yet been reported

Inactive Publication Date: 2018-05-01
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of isoglycyrrhizic acid and its salts or solvates of isoglycyrrhizic acid and its salts in the treatment of hyperuricemia has not yet been reported

Method used

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  • Application of isoglycyrrhizic acid to preparation of drugs used for treating hyperuricemia
  • Application of isoglycyrrhizic acid to preparation of drugs used for treating hyperuricemia
  • Application of isoglycyrrhizic acid to preparation of drugs used for treating hyperuricemia

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Experimental materials:

[0026] 1.1 Animals:

[0027] Male Sprague-Dawley (SD) rats (180-220 g).

[0028] 1.2 Feeding conditions:

[0029] The room temperature is 22-24°C, the relative humidity is 50-60%, and the light and dark alternate 12h / 12h every day (lights are turned on from 9:00 am to 21:00 pm). The animals had free access to experimental animal feed and drinking water.

[0030] 1.3 Reagents:

[0031] Magnesium isoglycyrrhizinate (as shown in formula III) is dissolved in normal saline, and is formulated into a concentration of 5 mg / mL;

[0032] Animal serum uric acid and urine uric acid levels were measured using uric acid kits.

[0033] 2. Experimental method:

[0034] The animals were randomly divided into a normal blank control group (7-10 animals) and a model control group (28-40 animals), and were reared in separate cages. Animals in the normal blank control group freely ingested feed and drinking water; animals in the model control group ingeste...

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Abstract

The invention discloses application of isoglycyrrhizic acid to preparation of drugs used for treating hyperuricemia, belonging to the field of medicines. Magnesium isoglycyrrhizinate can effectively reduce the level of serum uric acid in rats of a high-fructose diet model, increase the level of urine uric acid in the rats and promote excretion of uric acid. The invention also relates to application of isoglycyrrhizic acid and salts thereof or solvates of isoglycyrrhizic acid and salts thereof to drugs used for treating primary hyperuricemia or secondary hyperuricemia or hyperuricemia accompanied by hypertension.

Description

technical field [0001] The invention belongs to the field of medicine, in particular, the invention relates to the application of isoglycyrrhizic acid and its salt or the solvate of isoglycyrrhizic acid and its salt in the preparation of medicine for treating hyperuricemia. Background technique [0002] Hyperuricemia (HUA) is a metabolic disease caused by an increase in uric acid synthesis and / or a decrease in excretion due to purine metabolism disorders. It can be divided into primary hyperuricemia and secondary hyperuricemia. Two categories of diseases. [0003] Primary hyperuricemia refers to an increase in serum uric acid level or urate deposition caused by a congenital uric acid metabolism disorder, and the clinical manifestations are mainly gout syndrome. Secondary hyperuricemia is a clinical manifestation of elevated serum uric acid levels secondary to one or more acquired diseases or drug effects. Among them, acquired diseases can be blood diseases (such as polycyt...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P19/06A61P9/12
CPCA61K31/704
Inventor 顾红梅徐宏江孔令东宋伟施伟赵晓娟杨颜滋
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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