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Composition for preparing products for improving hyperuricemia

A technology of hyperuricemia and composition, which is applied in the field of composition for improving hyperuricemia, can solve problems such as toxic and side effects, human injury, etc., achieve excellent effects, and contribute to the effect of gout

Inactive Publication Date: 2013-04-10
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the active ingredients for the prevention and treatment of hyperuricemia mainly include carbensulfonamide, sulfazone, benzbromarone, allopurinol, etc. Most of these ingredients are obtained through chemical synthesis, and generally have certain toxicity. Side effects, great damage to the human body

Method used

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  • Composition for preparing products for improving hyperuricemia
  • Composition for preparing products for improving hyperuricemia
  • Composition for preparing products for improving hyperuricemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1. Materials and methods

[0033] (1) Animal model establishment

[0034] Select male Kunming mice, add 20% by weight of yeast extract powder in the feed, orally orally for 2 weeks continuously, and establish an animal mouse model with hyperuricemia.

[0035] (2) Preparation of experimental supplies

[0036] Saponin: Take 100g of crushed dry sea cucumber powder, add 1L of 60% ethanol solution to heat reflux extraction for 1 hour, repeat the operation 6 times, combine the supernatant obtained from each extraction, concentrate under reduced pressure to remove ethanol to obtain a concentrated solution, and then use saturated Butanol: water (1:1, v / v) extracts the concentrated solution, collects the supernatant, and evaporates to dryness to obtain saponin.

[0037] (3) Experimental process

[0038] Select 24 male Kunming mice, weighing 20±5g, and randomly divide them into 4 groups with 6 mice in each group. The normal group and the hyperuricemia model group were intragas...

Embodiment 2

[0050] 1. Materials and methods

[0051] (1) Animal model establishment

[0052] Select male Kunming mice, add 20% by weight of yeast extract powder in the feed, orally orally for 2 weeks continuously, and establish an animal mouse model with hyperuricemia.

[0053] (2) Preparation of experimental supplies

[0054]Polysaccharide: Remove the sediment from the dried sea cucumber and crush it, weigh 100g, 2L 0.1M sodium acetate buffer solution (pH=6), 2.92g EDTA, 1.21g cysteine ​​and 100mg papain, stir and react in a water bath at 60°C for 24h Afterwards, the reaction mixture was centrifuged (4900 xg, 10 min). Add 2 times the volume of 95% ethanol solution to the supernatant, ie sea cucumber enzymatic hydrolysis solution, place at 4°C for 24 hours, and centrifuge (4900×g, 10 min). Add 100mL distilled water to the precipitate to redissolve, add 5-10mL trichloroacetic acid, place at 4°C for 4h, and centrifuge (4900×g, 10min). The supernatant was taken, dialyzed with a dialysis ...

Embodiment 3

[0067] 1. Materials and methods

[0068] (1) Animal model establishment

[0069] Select male Kunming mice, add 20% yeast extract powder to the feed, orally orally for 2W continuously, and establish an animal mouse model with hyperuricemia.

[0070] (2) Preparation of experimental supplies

[0071] The preparation scheme of sea cucumber saponin and sea cucumber polysaccharide is the same as that of Experimental Example 1 and Experimental Example 2.

[0072] (3) Experimental method

[0073] 30 male Kunming mice, weighing 20±5g, were randomly divided into 5 groups, 6 mice in each group. The normal group and the hyperuricemia model group were given normal saline at a dose of 100 mg / kg every day, and the saponin group was given intragastric administration. The polysaccharide group was given 3% saponin solution, the polysaccharide group was given 30% polysaccharide solution by intragastric administration, and the sea cucumber saponin and sea cucumber polysaccharide compound group...

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Abstract

The invention provides a composition and application of the composition in the preparation of medicaments, health-care food or functional food for preventing and treating hyperuricemia. The composition comprises at least one of holothuria saponins and holothuria polysaccharides, wherein the holothuria saponins are main secondary metabolites in holothuria, and have various physiological and pharmacological activity of hemolysis, fungus resistance, cytotoxicity, tumor resistance, immunoregulation, antioxidation, blood fat reduction and the like and have high medicinal value; the holothuria polysaccharides are important ingredients of holothuria body walls, and have the pharmacological activity of anticoagulation, thrombus resistance, tumor resistance, immunoregulation and the like. Animal experiments prove that the prepared composition containing at least one of the holothuria saponins and the holothuria polysaccharides can improve the serum uric acid level of animals in vivo obviously so as to prevent and treat the hyperuricemia.

Description

technical field [0001] The invention relates to a composition for preparing products for improving diseases, in particular to a composition for improving hyperuricemia. Background technique [0002] The latest epidemiological studies show that the incidence of gout is increasing year by year. Primary gout is significantly positively correlated with obesity, hyperlipidemia, hypertension, diabetes, atherosclerosis and other diseases. [0003] Gout is a disease caused by purine metabolism disorder in the human body. It is mainly due to the increase of uric acid production and the decrease of uric acid excretion, which lead to the pathophysiological changes caused by the deposition of uric acid in the body, manifested as hyperuricemia, and repeated attacks can cause gouty acute arthritis. , tophi, uric acid nephropathy, often accompanied by urinary tract stones, severe cases present a series of complications such as joint deformity and dysfunction, which seriously threaten peop...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/56A23L1/29A61P19/06A23L33/00A61K35/616
Inventor 张灏徐慧静王玉明于林芳薛勇徐杰李兆杰常耀光唐庆娟王静凤薛长湖
Owner OCEAN UNIV OF CHINA
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