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Topical and transdermal delivery of an iron chelator to prevent and treat chronic wounds

A technology of iron chelating agent and transdermal patch, which is applied in the direction of drug combination, skin disease, drug delivery, etc., and can solve problems such as not involved

Pending Publication Date: 2020-12-18
陶托纳集团知识产权控股有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these publications describe the use of DFO to treat pressure ulcers in the skin of diabetic mice, they do not refer to the use of DFO delivered into the dermis from a delivery device applied to the skin surface to treat SCU

Method used

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  • Topical and transdermal delivery of an iron chelator to prevent and treat chronic wounds
  • Topical and transdermal delivery of an iron chelator to prevent and treat chronic wounds
  • Topical and transdermal delivery of an iron chelator to prevent and treat chronic wounds

Examples

Experimental program
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Effect test

Embodiment 1

[0063] Proposed mechanisms of healing were explored using sickle cell mouse studies (Rodrigues et al., in press). In this study, the transgenic sickle cell mouse model HbSS-BERK was used to determine the utility of DIDP. These mice do not express mouse hemoglobin and carry transgenic copies containing human α1, γ, δ and β-sickle genes on a mixed genetic background. It recapitulates human sickle cell disease, including hemolysis, reticulocytosis, anemia, extensive organ damage, shortened lifespan, and pain.

[0064] As described in more detail below, wound healing was significantly slower in SCD mice than in wild-type mice (***p<0.001). Wounds treated with DFO-TDDS (TDDS is synonymous with DIDP) showed significantly accelerated closure time, size compared to untreated wounds (***p<0.001) and DFO injection-treated (*p<0.05) Reduction and improved wound reconstruction. DFO released from TDDS into the wound results in the sequestration of excess dermal free iron.

[0065] mo...

Embodiment 2

[0089] To study the ability of an intradermal patch containing an iron chelator such as DFO to deliver DFO into the human dermis, a vertical Franz diffusion cell ( Figure 8 ) to evaluate DIDP. Full-thickness human skin samples obtained with Stanford University IRB approval were mounted between the two compartments of the diffusion cell with the cuticle facing the donor compartment. DIDP was applied, and the isotonic phosphate buffer solution was stirred with a magnetic stirrer and maintained at 37 °C by a circulating water jacket. Over the course of 15 hours, skin samples were removed hourly, washed with phosphate-buffered saline (PBS) and dried with absorbent towels. Skin samples were frozen at -20°C and cut into 20 μm sections with a microtome. Samples were analyzed spectrophotometrically at 560 nm (Shimadzu, Japan) for drug content and relative DFO concentrations were determined.

[0090] Skin biopsies of fresh full-thickness skin samples used in the post-DIDP Franz poo...

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Abstract

A transdermal patch for the treatment of Sickle Cell Ulcers is provided. The patch can facilitate the delivery of an iron chelator, such as DFO. The DFO can be encapsulated in a reverse micelle to enhance penetration into and absorption by the dermis. The patch can be used to accelerate healing and reduce pain associated with Sickle Cell Ulcers.

Description

[0001] incorporated by reference [0002] All publications and patent applications mentioned in this specification are herein incorporated by reference in their entirety to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference. Background technique [0003] Chronic wounds that do not heal pose challenges for patients, healthcare professionals, and healthcare systems. It severely impairs the quality of life of millions of people and burdens society in lost productivity and healthcare costs. [0004] Wound healing is a dynamic pathway that optimally leads to restoration of tissue integrity and function. Chronic trauma results when normal repair processes are interrupted. By understanding the biology of wound healing, physicians can optimize the tissue environment in which the wound resides. Wound healing is the result of cumulative processes including coagulation, inflammation, basal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/10A61K31/164
CPCA61K31/16A61K9/1075A61K9/0014A61K9/7053A61K9/7069A61K47/38A61K47/32A61K47/34A61P17/02A61K9/703
Inventor G·C·古特尼尔
Owner 陶托纳集团知识产权控股有限责任公司
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