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Acupuncture needle capable of enhancing pain relieving effect as well as preparation method and application thereof

A technology of acupuncture needles and efficacy, applied in the field of acupuncture needles, can solve problems such as severe pain and difficulty, achieve the effect of promoting energy metabolism, maintaining long time, and enhancing cell vitality

Pending Publication Date: 2020-12-25
CHANGCHUN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for the pain of lumbar metastases, compared with common pain such as cervical spondylosis and pain caused by lumbar disc herniation, the pain of lumbar metastases is more severe, the pain gradually increases, and the pain site is relatively fixed. There is a history of cancer, so the treatment of lumbar metastases Pain is more difficult to treat than ordinary pain. Lumbar metastatic cancer pain is significantly stronger than ordinary pain. At present, there is no record of drugs that can significantly enhance the pain relief effect loaded on acupuncture needles, and there is no effective drug for lumbar metastases. There are no records on acupuncture needles, and no reports on its treatment of related diseases

Method used

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  • Acupuncture needle capable of enhancing pain relieving effect as well as preparation method and application thereof
  • Acupuncture needle capable of enhancing pain relieving effect as well as preparation method and application thereof

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preparation example Construction

[0026] The present invention also provides a drug coating capable of enhancing the analgesic effect, and the drug coating is made of the above-mentioned drug composition. In the present invention, there is no special limitation on the method for preparing the drug coating from the above pharmaceutical composition, and conventional methods in the art for preparing the drug coating can be used. Preferably, the preparation method of the above-mentioned drug coating comprises the following steps:

[0027] (1) preparing alcohol extracts of Radix Astragali, Codonopsis Radix, Cinnamon, Asarum, Salvia Miltiorrhiza, Frankincense and Myrrh;

[0028] (2) Mix polylactic acid polyglycolic acid copolymer solution with lidocaine, vitamin E acetate and the alcohol extract obtained in step (1), stir and dissolve to obtain a drug coating.

[0029] In the present invention, astragalus, Codonopsis pilosula, cinnamon, asarum, salvia miltiorrhiza, frankincense and myrrh are subjected to alcohol ex...

Embodiment 1

[0036] (1) Reflux extract 20g of Astragalus membranaceus, 20g of Codonopsis pilosula, 20g of cinnamon, 5g of asarum, 20g of salvia miltiorrhiza, 20g of frankincense and 20g of myrrh with 90% ethanol for 3 times, each time for 2h, and collect the extract obtained by reflux for 3 times , concentrated under vacuum at 0.05 MPa to 80.4% of the active ingredient content of the concentrated solution, and dried for 30 minutes by spray drying with an air inlet temperature of 168° C. to obtain 40 g of alcohol extract.

[0037] (2) PLGA with a mass ratio of glycolide and lactide of 1:1 is added to the chloroform solution for dissolution to obtain a PLGA chloroform solution with a PLGA mass concentration of 2%. Mix 80g of PLGA in chloroform with 40g of lidocaine, vitamin E acetate 20g and the ethanol extract obtained in step (1) are mixed, stirred and dissolved to obtain a drug coating.

[0038] (3) The drug coating was sprayed on the surface of the acupuncture needles by spraying at a sp...

Embodiment 2

[0040] (1) 16g of Astragalus membranaceus, 16g of Codonopsis pilosula, 16g of cinnamon, 4g of asarum, 16g of salvia miltiorrhiza, 16g of frankincense and 16g of myrrh were refluxed with 92% ethanol for 4 times, each time for 1.5h, and the extraction obtained from 4 times of reflux was collected liquid, concentrated under vacuum at 0.04 MPa until the active ingredient content of the concentrated liquid was 83%, and dried for 15 minutes by spray drying at an air inlet temperature of 169° C. to obtain 32 g of alcohol extract.

[0041] (2) PLGA with a mass ratio of glycolide and lactide of 2:3 is added to the chloroform solution for dissolution to obtain a PLGA chloroform solution with a PLGA mass concentration of 1%. Mix 64g of PLGA in chloroform with 32g of lidocaine, vitamin E acetate 16g and the ethanol extract obtained in step (1) are mixed, stirred and dissolved to obtain a drug coating.

[0042] (3) The drug coating was sprayed on the surface of acupuncture needles by spray...

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Abstract

The invention provides an acupuncture needle capable of enhancing the pain relieving effect as well as a preparation method and application thereof, and belongs to the technical field of acupuncture needles. According to the invention, effective components capable of enhancing the pain relieving effect, especially effectively treating lumbar metastatic cancer pain, are extracted from medicines such as radix astragali, radix codonopsis, cortex cinnamomi, herba asari, radix salviae miltiorrhizae, frankincense and myrrh, lidocaine and vitamin E acetate are used as auxiliary materials, a proper high polymer material PLGA is used as a skeleton, a film layer containing analgesic active ingredients is formed on the surface of the acupuncture needle through a spraying method, and the high polymermaterial PLGA used for medicine carrying can be stably combined with active ingredients of the traditional Chinese medicines and can be rapidly released in a human body, so that the medicine penetration amount is increased, and good effects of enhancing the analgesic effect and treating the lumbar metastatic carcinoma pain are achieved through clinical tests.

Description

technical field [0001] The invention belongs to the technical field of acupuncture needles, and in particular relates to an acupuncture needle capable of enhancing analgesic effect, a preparation method and application thereof. Background technique [0002] With the rapid development of society, people's awareness of health care is gradually strengthened, and the requirements for diagnosis and treatment methods and effects are increasing day by day. Traditional non-drug therapies are showing a better and better development trend. , convenience and other characteristics, the performance is the most prominent. However, relying solely on acupuncture and moxibustion still has many disadvantages, such as the narrow range of acupuncture and moxibustion, and the treatment effect on some diseases is slow or weak. Therapies combine to form a new treatment. In my country, the research on drug-loaded acupuncture needles has achieved initial results. At present, there are some records...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61K47/34A61P29/00A61P35/00A61H39/08A61L31/16A61L31/08A61L31/10A61L31/14A61K31/167A61K31/355
CPCA61H39/086A61H2201/105A61K31/167A61K31/355A61K36/268A61K36/324A61K36/328A61K36/344A61K36/481A61K36/537A61K36/54A61K47/34A61K2236/333A61K2236/39A61L31/08A61L31/10A61L31/14A61L31/16A61L2300/30A61L2300/402A61L2300/428A61L2300/45A61L2300/606A61P29/00A61P35/00A61K2300/00C08L67/04
Inventor 丁庆刚旋菲张文龙旋静冯长卓高楠张丁亓李岫孙文哲诸葛续文
Owner CHANGCHUN UNIV OF CHINESE MEDICINE
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