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Diagnosis and treatment integrated hollow carbon nano composite material as well as preparation method and application thereof

A composite material and carbon nanotechnology, which is used in medical preparations with non-active ingredients, medical preparations containing active ingredients, and drug combinations, etc., can solve problems such as confusion, tissue calcification, and affect the accuracy of diagnosis, and achieve image brightness. Increased efficacy, low in vitro cytotoxicity, good biosafety

Active Publication Date: 2021-01-05
FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Patent CN 111494627 A discloses a light, heat and magnetic composite material based on hollow carbon spheres, based on hollow nanoparticles UCNPs / Fe coated with hollow carbon shells 3 o 4 @h-C, UCNPs and Fe 3 o 4 Nanoparticles were introduced into the interior of hollow carbon spheres, and the prepared hollow carbon-coated UCNPs and Fe 3 o 4 Synthesized nanoparticles with core-shell structure, although they can meet certain needs of integration of photothermal therapy and imaging diagnosis and treatment, in MRI, only negative contrast agent T 2 , its detection signal is easily confused with metal deposition, tissue calcification, etc., which affects the accuracy of diagnosis

Method used

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  • Diagnosis and treatment integrated hollow carbon nano composite material as well as preparation method and application thereof
  • Diagnosis and treatment integrated hollow carbon nano composite material as well as preparation method and application thereof
  • Diagnosis and treatment integrated hollow carbon nano composite material as well as preparation method and application thereof

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Effect test

Embodiment 1

[0046] 1) The specific process is as follows: the purchased commercial SiO 2 (70-80nm) 10mg was dispersed in 50mL ethanol solution, after stirring at room temperature for 1h, 0.6g of resole phenolic resin (RF) solution with a concentration of 160mg / mL was added. After continuing to stir for 24h, the mixture was transferred to an 80mL reactor, and subjected to hydrothermal reaction at 100°C for 24h. After cooling to room temperature, the obtained sample was centrifuged and washed with water, and then dried in an oven at 60°C for 12 hours to obtain SiO 2 @RF polymer pellets.

[0047] 2) 6mg{Fe 6 Gd 6 P 6} sonicated into 2 mL of ethanol solution, and to this solution was added 20 mg of SiO 2 @RF, sonication makes it uniform in ethanol solution. The mixed solution was stirred and evaporated to dryness at room temperature to obtain SiO 2 @RF-{Fe 6 Gd 6 P 6} composite material.

[0048] 3) Put the above-mentioned obtained material in a tube furnace, roast at 600 ° C for 1...

Embodiment 3

[0064] The biopsy tissue slice test of the sample in Example 3, the method is as follows: take the tissue organs of nude mice after injecting the nanocomposite material for 24 hours, wash them with normal saline or PBS, put them into 4% paraformaldehyde for fixation, and dehydrate Transparent, wax-soaked, embedded, trimmed, sliced, patched, fished, baked, dewaxed to water, dyed, dehydrated, mounted and photographed, such as Figure 8 shown.

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Abstract

The invention relates to the technical field of functional nano materials, in particular to a diagnosis and treatment integrated hollow carbon nano composite material and a preparation method thereof.Due to the hollow structure of the hollow carbon nano composite material, the requirement of photoacoustic imaging is met. Meanwhile, paramagnetic gadolinium phosphate nanoparticles and superparamagnetic gamma iron oxide nanoparticles are uniformly distributed in a shell layer of hollow carbon, so that the requirements of T1 weighted imaging and T2 weighted imaging are met. On the other hand, thehollow carbon material can be used as a drug carrier due to the porosity of the hollow carbon material, and the drug delivery function is achieved. Therefore, the nano material provided by the invention realizes the integration of T1 and T2 nuclear magnetic resonance contrast imaging, photoacoustic contrast imaging and drug delivery functions. The biological safety of the obtained nano diagnosisand treatment integrated material is verified at the cellular level and the mouse level, and the nano diagnosis and treatment integrated material has potential application prospects.

Description

technical field [0001] The invention relates to the technical field of functional nanomaterials, in particular to a hollow carbon nanocomposite material integrating diagnosis and treatment, a preparation method and application thereof. Background technique [0002] With the continuous development of nano-material technology, tumor treatment technology (including: chemical drug therapy, gene therapy, photodynamic therapy, photothermal therapy, immunotherapy, etc.) and tumor diagnostic methods (including: nuclear magnetic resonance imaging, photoacoustic imaging , positron emission tomography, computed tomography, etc.) are integrated into a material through modern nanosynthesis technology to achieve functional integration, which is not only conducive to patient stratification and personalized medicine, but also to real-time monitoring of nanomedicine therapy. Therefore, the development of integrated nanomaterials for diagnosis and treatment is one of the development direction...

Claims

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Application Information

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IPC IPC(8): A61K49/18A61K49/08A61K49/22A61K9/51A61K47/04A61K31/704A61P35/00
CPCA61K9/5115A61K31/704A61K49/08A61K49/18A61K49/225A61P35/00
Inventor 凌云周亚明刘小锋杨永泰贾瑜陈珍霞邓名莉张慧
Owner FUDAN UNIV
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