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Application of 3-(iso)quinoline substituted flavonoid derivatives as antifungal active ingredients

A technology of active ingredients and flavonoids, applied in the field of antifungal applications, can solve the problems of poor antibacterial activity and inability to achieve application, and achieve the effect of significant inhibitory activity and broad-spectrum antifungal activity

Active Publication Date: 2021-09-21
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing flavonoids cannot be further applied due to problems such as poor antibacterial activity.

Method used

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  • Application of 3-(iso)quinoline substituted flavonoid derivatives as antifungal active ingredients
  • Application of 3-(iso)quinoline substituted flavonoid derivatives as antifungal active ingredients
  • Application of 3-(iso)quinoline substituted flavonoid derivatives as antifungal active ingredients

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Embodiment 1

[0013] According to the publication number CN110790752A, the title of the invention is "a kind of synthesis method of flavone and quinolone derivatives substituted by (iso) quinoline and quinoxaline" to synthesize the 3-quinoline shown in the following formulas 1-20 Substituted flavonoid derivatives, and 3-isoquinoline substituted flavonoid derivatives represented by formulas 21-33.

[0014]

[0015]

[0016]

[0017]

[0018] 1. Experimental method

[0019] Using the mycelia linear growth rate method, the compounds of formulas 1 to 33 were tested against seven kinds of cucumber anthracnose, watermelon wilt, rape sclerotinia, apple rot fungus, apple rot fungus, tobacco red spot fungus and botrytis cinerea. In vitro inhibitory activity of phytopathogenic fungi. The selected fungi were provided by the Plant Protection School of Northwest A&F University.

[0020] With 50 mg / L quercetin and chlorothalonil solutions as positive controls and 5% DMSO aqueous solution as...

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Abstract

The invention discloses the application of a 3-position (iso)quinoline substituted flavonoid derivative as an antifungal active ingredient. The result shows that quinoline or isoquinolinyl substituted flavonoid derivatives of the present invention have broad-spectrum antifungal activity, especially significant inhibitory activity to Sclerotinia sclerotiorum, apple rot pathogen and Botrytis cinerea. The (iso)quinoline-substituted flavonoid derivatives provide the basis for novel fungicides with active ingredients.

Description

technical field [0001] The invention belongs to the technical field of medicinal chemistry, and specifically relates to the antifungal application of a 3-position (iso)quinoline substituted flavonoid derivative. Background technique [0002] Flavonoids, also known as flavonoids, are a class of natural products that widely exist in nature, especially in plants. According to the different substituents on the A, B and C rings and the differences in chemical properties, flavonoids can be divided into 14 categories, including flavones, isoflavones, chalcones, flavonols, dihydroflavones and chromones, etc. . Since Walz successfully isolated soybean isoflavone glycosides from legumes in 1931, the study of flavonoids has always been the focus of domestic and foreign scientists. Studies have found that flavonoids have certain antibacterial effects. The antibacterial mechanisms of these compounds mainly include: inhibiting the energy metabolism of bacteria, interfering with the cell...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/42A01P3/00
CPCA01N43/42
Inventor 王涛张珊吴纯张尊听
Owner SHAANXI NORMAL UNIV