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Traditional Chinese medicine cream for treating hyperplasia of mammary glands and preparation method thereof

A technology of mammary gland hyperplasia and traditional Chinese medicine, which is applied in the direction of medical formula, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. question

Pending Publication Date: 2021-01-19
NANYANG INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this invention, Chinese medicine components are coated in a polymer material made of polylactic acid and poly-3-hydroxybutyrate, which can effectively improve breast pain, breast lumps, nipple discharge and other symptoms caused by female mammary gland hyperplasia. The preparation method of transdermal patch is cumbersome, the compatibility of traditional Chinese medicine is complicated, and the curative effect is not clear

Method used

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  • Traditional Chinese medicine cream for treating hyperplasia of mammary glands and preparation method thereof
  • Traditional Chinese medicine cream for treating hyperplasia of mammary glands and preparation method thereof
  • Traditional Chinese medicine cream for treating hyperplasia of mammary glands and preparation method thereof

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preparation example Construction

[0044] The preparation method of the above-mentioned Chinese medicine emulsifiable paste for mammary gland hyperplasia, comprises the following steps:

[0045] (1) Ethanol extraction: mix and grind zedoary, mango flower, chestnut shell, sweet orange, red zebra, leaking reed, white back maple, rose, artemisia annua, mugwort leaf and arrowroot, add 6-8 times the amount 95% ethanol, reflux extraction 2-3 times, each time 1-2h, combined ethanol extract, filtered, the filtrate was concentrated under reduced pressure to an extract with a relative density of 1.3-1.4 at 60°C, and set aside;

[0046] (2) Water extraction: Add 8-10 times the amount of purified water to the dregs obtained by filtering in step (1), heat and extract 2-3 times, 2 hours each time, combine the extracts, filter, and concentrate the filtrate to 60 The extract with a relative density of 1.3-1.4 at ℃, for later use;

[0047] (3) Oil phase preparation: take the oil phase base, heat it to 75°C to melt, use it as t...

Embodiment 1

[0055] A traditional Chinese medicine cream for mammary gland hyperplasia, which is made from the following raw materials: 15g of curcuma, 20g of awn seed flower, 15g of chestnut shell, 15g of sweet orange, 15g of red eupatorium, 10g of leaking reed, 8g of white back maple, and 8g of rose , Artemisia annua 8g, mugwort leaves 6g, arrowroot mosaic 5g, borneol 3g.

[0056] The preparation method of the above-mentioned Chinese medicine emulsifiable paste for mammary gland hyperplasia, comprises the following steps:

[0057] (1) Ethanol extraction: mix and grind curcuma, mango, chestnut husk, sweet orange, red zebra, leaking reed, white back maple, rose, artemisia annua, mugwort leaves and arrowroot, with a particle size of 10-20 For the purpose, add 7 times the amount of 95% ethanol, reflux extraction 3 times, each time for 1.5h, combine the ethanol extract, filter, and concentrate the filtrate under reduced pressure to an extract with a relative density of 1.32 at 60°C, and set a...

Embodiment 2

[0067] A traditional Chinese medicine cream for mammary gland hyperplasia, which is made from the following raw materials: 25g of curcuma, 35g of awn seed flower, 25g of chestnut shell, 20g of sweet orange, 20g of red eupatorium, 15g of leaking reed, 12g of white back maple, and 10g of rose , Artemisia annua 10g, mugwort leaves 10g, arrowroot mosaic 10g, borneol 5g.

[0068] The preparation method of the above-mentioned Chinese medicine emulsifiable paste for mammary gland hyperplasia, comprises the following steps:

[0069] (1) Ethanol extraction: mix and grind curcuma, mango, chestnut husk, sweet orange, red zebra, leaking reed, white back maple, rose, artemisia annua, mugwort leaves and arrowroot, with a particle size of 10-20 Add 8 times the amount of 95% ethanol, reflux extraction 3 times, 1 hour each time, combine the ethanol extracts, filter, and concentrate the filtrate under reduced pressure to an extract with a relative density of 1.4 at 60°C for subsequent use;

[...

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Abstract

The invention discloses traditional Chinese medicine cream for treating hyperplasia of mammary glands and a preparation method thereof, and relates to the field of pharmaceutical chemicals. The traditional Chinese medicine cream for treating hyperplasia of mammary glands is prepared from the following raw materials in parts by weight: 10-25 parts of curcuma zedoary, 10-35 parts of hypericum uralum, 10-25 parts of chestnut shells, 10-20 parts of sweet oranges, 10-20 parts of Japanese conehead herb, 5-15 parts of uniflower swisscentaury root, 5-12 parts of buddleja asiatica, 5-10 parts of roses,5-10 parts of sweet wormwood, 1-10 parts of folium artemisiae argyi, 1-10 parts of caladium bicolor and 1-5 parts of borneol. The traditional Chinese medicine cream disclosed by the invention is usedfor treating hyperplasia of mammary glands; through external administration, the density of lobules of mammary glands and the specific surface area of acinus can be obviously reduced, and the densityof mesenchyme of lobules of mammary glands is obviously increased; and the estradiol level in rat serum is obviously reduced, the progesterone level is obviously increased, and the traditional Chinese medicine cream has an obvious treatment effect on hyperplasia of mammary glands.

Description

technical field [0001] The invention relates to the field of medicine and chemical industry, in particular to a traditional Chinese medicine cream for mammary gland hyperplasia and a preparation method thereof. Background technique [0002] Mammary gland hyperplasia is a common gynecological disease, which is a general term for a class of diseases whose main pathological changes are epithelial cells and connective tissue hyperplasia in mammary acini and ducts. It is neither an inflammation nor a tumor. It is clinically characterized by breast pain and lumps, and its severity changes with the menstrual cycle and emotional changes. The incidence of mammary gland hyperplasia accounts for about 40% of women of childbearing age, accounts for 75% of breast diseases, and is the most common breast disease. With the progress of society, the development of economy and the change of ecological environment, the incidence rate shows a clear upward trend. Epidemiological data show that ...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/06A61K47/14A61K47/10A61P15/14A61K31/045
CPCA61K36/9066A61K36/38A61K36/49A61K36/752A61K36/195A61K36/28A61K36/56A61K36/738A61K36/282A61K36/88A61K31/045A61K9/06A61K9/0014A61K47/14A61K47/10A61P15/14A61K2236/333A61K2236/331A61K2236/51A61K2300/00
Inventor 高丽张瓅方封貌黄显章张超云李超
Owner NANYANG INST OF TECH
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