Intracranial deep electrode recording device and preparation method and system thereof

Abstract

The invention discloses an intracranial deep electrode recording device and a preparation method and system thereof. The intracranial deep electrode recording device comprises a flexible substrate, afirst metal layer, a flexible packaging layer and a second metal layer, wherein the first metal layer is located on the flexible substrate, and the first metal layer sequentially comprises a rear-endwiring part, a metal interconnection part and a plurality of electrode monitoring wiring parts arranged at intervals; the flexible packaging layer covers the first metal layer; and the second metal layer is located on the flexible packaging layer, wherein one end of each electrode monitoring site is connected with a corresponding metal contact point in the corresponding electrode monitoring wiringpart through a through hole formed in the flexible packaging layer, and the other end of each electrode monitoring site is exposed outside to be used for monitoring intracranial biological signals. According to the intracranial deep electrode recording device, the minimum device size and the maximum flexibility are achieved, the effective bending rigidity and tissue displacement of the device aregreatly reduced, and the long-term biocompatibility of the device is remarkably improved.

Description

technical field [0001] The present invention The present application relates to the technical field of brain-computer interface, in particular to an intracranial deep electrode recording device and a preparation method and system thereof. Background technique [0002] Among many brain diseases, epilepsy is different from degenerative neurological diseases such as Alzheimer and Parkinson and mental diseases such as depression. It is a chronic brain disease that spans the entire life cycle of individuals across races, ages and genders . Epileptic seizures originate from the sudden abnormal discharge of neurons in a specific brain area (epileptic focus), which is transmitted to various functional areas of the whole brain through nerve conduction pathways, and eventually leads to transient brain dysfunction and physical disability. [0003] Usually, for some refractory epilepsy patients who cannot rely on drug therapy to control their disease, it is necessary to adopt methods s...

AI Technical Summary

Problems solved by technology

[0004] However, the existing sEEG stereotaxic deep electrodes are all insulated microwire electrodes. After surgically implanted into the brain tissue, due to the large size of the insulated microwire electrodes and the difference in mechanical properties, not only the electrode and the brain tissue often have Relatively micro-moving and causing inflammatory reactions, and the electrodes implanted with the size of the surgical imprint and the degree of trauma cover a large total area of ​​the brain, making it difficult to achieve long-term in vivo stable recording of electrophysiological signals in deep brain structures

Images