A deep intracranial electrode recording device and its preparation method and system
A deep electrode and device technology, applied in the field of intracranial deep electrode recording device and its preparation, can solve the problems of large total brain area, inflammatory response, difficulty in achieving long-term stable recording of deep brain structure electrophysiological signals in vivo, and the like. Minimized, reduced effective bend, maximized flexibility
Active Publication Date: 2022-03-25
SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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Problems solved by technology
[0004] However, the existing sEEG stereotaxic deep electrodes are all insulated microwire electrodes. After surgically implanted into the brain tissue, due to the large size of the insulated microwire electrodes and the difference in mechanical properties, not only the electrode and the brain tissue often have Relatively micro-moving and causing inflammatory reactions, and the electrodes implanted with the size of the surgical imprint and the degree of trauma cover a large total area of the brain, making it difficult to achieve long-term in vivo stable recording of electrophysiological signals in deep brain structures
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[0050] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, but not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present application.
[0051] References hereinafter to "one embodiment" or "an embodiment" and the like refer to a particular feature, structure, or characteristic that may be included in at least one implementation of the present invention. In the description of the present invention, it should be understood that the orientations or positional relationships indicated by the terms "upper", "lower", "left", "right", "top", "bottom", etc. are based on those shown i...
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The present application discloses a deep intracranial electrode recording device and its preparation method and system, which includes a flexible substrate, the first metal layer on the flexible substrate, which in turn includes a rear-end wiring part, a metal interconnection part and a plurality of Electrode monitoring wiring parts arranged at intervals; a flexible packaging layer covering the first metal layer; a second metal layer located on the flexible packaging layer, wherein one end of each electrode monitoring site is connected to the through hole opened in the flexible packaging layer The electrodes are connected to corresponding metal contact points in the monitoring wiring part, and the other end is exposed for monitoring intracranial biological signals. The intracranial deep electrode recording device of the present application realizes the smallest device volume and maximized flexibility, and greatly reduces the effective bending stiffness and tissue displacement of the device, and significantly improves its long-term biocompatibility.
Description
technical field [0001] The present invention relates to the technical field of brain-computer interfaces, and in particular, to an intracranial deep electrode recording device and a preparation method and system thereof. Background technique [0002] Among many brain diseases, epilepsy is different from degenerative neurological diseases such as Alzheimer's and Parkinson's and mental diseases such as depression. It is a chronic brain disease that spans the entire life cycle of individuals across races, ages and genders. . Epilepsy seizures originate from the sudden abnormal discharge of neurons in specific intracranial brain regions (epileptic foci), which are transmitted to various functional regions of the whole brain through nerve conduction pathways, and eventually lead to transient brain dysfunction and physical disability. [0003] Usually, for some patients with refractory epilepsy who cannot rely on drug therapy to control the disease, it is necessary to adopt metho...
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IPC IPC(8): A61B5/293
Inventor 陶虎梁佶智魏晓玲周志涛
Owner SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI