A kind of biodegradable bioadhesive and preparation method thereof
A bioadhesive, biodegradable technology, applied in surgical adhesives, surgery, medical science, etc., can solve the problems of low bonding strength and slow bonding speed, and achieve simple use, good hydrophilicity, and moisturizing performance good effect
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[0044] As another aspect of the present invention, a method for preparing a biodegradable bioadhesive of the present invention comprises the following steps:
[0045] S1. Dissolve 1 part of polyacid amino acid in a mixed organic solvent of 10 to 100 parts of N, N-dimethylformamide and dimethyl sulfoxide, and add R 1 -NH 2 and R 2 -NH 2 , then add additives A and B, then add organic base catalyst C, and stir and react at 25-40°C for 4-12 hours;
[0046] S2, transfer the reaction solution obtained in S1 to an ice-water bath and cool to 0° C., add 5% ethanol ice deionized water (volume is N, N-dimethylformamide and dimethylformamide in step S1) to the reaction solution 10 to 20 times the volume of the sulfoxide-based organic mixed solvent), and after mixing evenly, transfer the solution to a dialysis membrane, and put the dialysis membrane into 5% ethanol ice deionized water for dialysis for 48 to 72 hours;
[0047] S3. Transfer the liquid obtained from the dialysis in S2 to ...
Embodiment 1
[0058] A biodegradable bioadhesive and a preparation method thereof, the preparation method is as follows:
[0059] S1. Dissolve 1 part of poly-L-glutamic acid in 10 parts of a mixed organic solvent of N,N-dimethylformamide and dimethyl sulfoxide at a volume ratio of 1:1, and add γ-aminopropyl tris Ethoxysilane and 1-(3,4-dihydroxyphenyl)-2-aminoethanol (the number of moles is 5% and 3% of the number of carboxyl groups in poly-L-glutamic acid, respectively), adding auxiliary agent 1- (3-Dimethylaminopropyl)-3-ethyl carbodiimide and N-hydroxysuccinimide (the number of moles is respectively 9% and 8% of the number of moles of carboxyl groups in poly-L-glutamic acid), add Triethylamine (the number of moles is 4% of the number of moles of carboxyl groups in poly-L-glutamic acid), stirred and reacted at 25°C for 12h;
[0060] S2. Transfer the reaction solution obtained in S1 to an ice-water bath, and add 20 times the volume of N,N-dimethylformamide and dimethyl sulfoxide organic m...
Embodiment 2
[0063] A biodegradable bioadhesive and a preparation method thereof, the preparation method is as follows:
[0064] S1. Dissolve 1 part of poly-L-glutamic acid in 100 parts of a mixed organic solvent of N,N-dimethylformamide and dimethyl sulfoxide at a volume ratio of 1:4, and add γ-aminopropyl trimethyl Oxysilane and 2-(3,4-dihydroxyphenyl)ethylamine (the number of moles is 1% and 5% of the number of moles of carboxyl groups in poly-L-glutamic acid, respectively), and the auxiliary agent 1-(3-di Methylaminopropyl)-3-ethyl carbodiimide and N-hydroxyl succinimide (the number of moles is respectively 9% and 9% of the number of moles of carboxyl groups in poly-L-glutamic acid), adding triethylamine ( The number of moles is 3% of the number of moles of carboxyl groups in poly-L-glutamic acid), stirred and reacted at 40°C for 4h;
[0065] S2. Transfer the reaction solution obtained in S1 to an ice-water bath, and add 10 times the volume of N,N-dimethylformamide and dimethyl sulfox...
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