Preparation method and use of artificial cannabidiol chylomicron

A technology of cannabidiol milk and cannabidiol, which is applied in the fields of food, health care products and biomedicine, can solve the problem of no artificial cannabidiol chyle, improve water solubility and bioavailability, and ensure chemical stability , Improve the effect of bioavailability

Pending Publication Date: 2021-02-09
西安力邦医美科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no related reports on artificial cannabidiol chylo

Method used

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  • Preparation method and use of artificial cannabidiol chylomicron
  • Preparation method and use of artificial cannabidiol chylomicron
  • Preparation method and use of artificial cannabidiol chylomicron

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Artificial cannabidiol chylo products contain 0.5% cannabidiol.

[0029] Artificial Cannabidiol Chyl Prescription:

[0030]

[0031]

[0032] Prescription amounts of lecithin, cholesterol, mono / diglycerides, cannabidiol, and V EUnder nitrogen protection, add it to 200mL medium chain oil, heat (65°C) and stir to dissolve it completely. Slowly add the cannabidiol oil solution into about 700mL of pure water / water for injection buffer solution stirred at a high speed by a shearing machine (3000r / min), and continue stirring for 30min under the condition of nitrogen protection to obtain the artificial cannabidiol chylogenetic milk solution. The artificial cannabidiol chylocolostrum solution is homogenized 7 times by a high-pressure homogenizer, the pressure is 100 MPa, and the temperature of the homogenization process is 50-65°C to obtain an artificial cannabidiol chylosol solution with a particle size range of 290nm±70nm. Dilute with water for injection b...

Embodiment 2

[0033] Example 2: The artificial cannabidiol chylo product contains 5% cannabidiol.

[0034] Artificial Cannabidiol Chyl Prescription:

[0035]

[0036]

[0037] The preparation method is the same as in Example 1.

Embodiment 3

[0038] Example 3: 10% cannabidiol is contained in the artificial cannabidiol chylo product.

[0039] Artificial Cannabidiol Chyl Prescription:

[0040] name weight ratio(%) Feed amount (g) Lecithin 2.0 20 cholesterol 0.05 0.5 monoglycerides 0.8 8.0 Diglycerides of fatty acids 0.1 2.0 Cannabidiol 10 100 Vitamin E Palmitate 0.01 0.1 medium chain oil 20 200

[0041] The second part of the preparation method example: the dosage range of each packaging material for the preparation of cannabidiol artificial chyloe

[0042] The present invention verifies the dosage ranges of the packaging materials of the listed artificial cannabidiol chylo. Under the process and conditions of the present invention, the consumption of cannabidiol 50g is kept constant, the consumption of medium chain oil is 200mL (20%), the consumption of vitamin E is at 0.5%, and the consumption of lecithin is verified at 0.5-10%. Any amount within t...

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Abstract

The present invention provides a preparation method and use of artificial cannabidiol chylomicron. Cannabidiol is wrapped in oil-phase cores of emulsion droplets on the premise of keeping a basic composition of simplified chylomicron. The artificial chylomicron wrapping the cannabidiol comprises the following main components: a phospholipid emulsifier, a fatty acid monoglyceride co-emulsifier, a fatty acid diglyceride co-emulsifier, cholesterol or cholic acid, cannabidiol (CBD) and a liquid oil phase. The artificial cannabidiol chylomicron can wrap the CBD in inner cores of the chylomicron, solves water solubility of the CBD and also ensures chemical stability of the CBD.

Description

technical field [0001] The invention relates to an artificial chyle, in particular to a preparation method and application of an artificial cannabidiol chyle, and belongs to the technical fields of food, health products and biomedicine. Background technique [0002] Cannabis has been cultivated around the world for centuries for medicinal, industrial and recreational use. Hemp belongs to Magnoliopsida, Urticales, Cannabinaceae, Cannabis, Cannabis sativa L., an annual herb. Includes delta-9 tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is the main psychoactive compound, while CBD is a non-psychoactive drug that is effective in treating epilepsy and other neuropsychiatric disorders. As a result, more and more CBD products are being promoted around the world. Commercial CBD products are primarily made from industrial alfalfa or hemp, which contain little or no THC, the non-addictive ingredient in marijuana. At present, more than a dozen related preparations are unde...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61K47/44A61K47/24A61K47/14A61K9/08A61K9/00A61P25/22A61P25/20A61P39/06A61P29/00A61P37/02A23L33/105A23L33/15A23L33/115A23L29/10A23L29/00
CPCA61K31/05A61K47/44A61K47/24A61K47/14A61K9/08A61K9/0019A61K9/0053A61P25/22A61P25/20A61P39/06A61P29/00A61P37/02A23L33/105A23L33/15A23L33/115A23L29/10A23L29/04A23L29/035A23V2002/00A23V2200/322A23V2200/302A23V2200/30A23V2200/324A23V2200/222A23V2250/21A23V2250/1842A23V2250/192A23V2250/182A23V2250/712A23V2250/1944A23V2250/124A23V2300/26
Inventor 陈涛多宏庆王维娇马玉樊王阳苏畅
Owner 西安力邦医美科技有限公司
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