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Composition of PKD inhibitor and anti-cancer drug and application of composition

An anticancer drug and composition technology, applied in the application of blocking the drug resistance of oral squamous cell carcinoma cells, in the field of PKD small molecule inhibitors, can solve the problems of poor efficacy and large adverse reactions in solid tumors, and achieve enhanced sensitivity , wide application value, the effect of improving sensitivity and specificity

Pending Publication Date: 2021-02-09
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cytotoxic drugs are still the subject of tumor treatment drugs, but there are problems such as poor curative effect on solid tumors, large adverse reactions, and easy drug resistance.

Method used

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  • Composition of PKD inhibitor and anti-cancer drug and application of composition
  • Composition of PKD inhibitor and anti-cancer drug and application of composition
  • Composition of PKD inhibitor and anti-cancer drug and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The application method of the PKD small molecule inhibitor provided by the present invention in blocking the drug resistance of oral squamous cell carcinoma cells, including (such as figure 1 shown),):

[0042] S101, establishment of drug-resistant human oral squamous cell carcinoma cell line Cal-27 / PTX;

[0043] S102, CCK8 detects the cell inhibition rate of different concentrations of PTX on Cal-27 / PTX

[0044] S103, Western blot detection of PKD expression in Cal-27 / PTX cells;

[0045] S104, Western blot detection of PKD2 phosphorylation and activation expression in Cal-27 / PTX cells treated with different concentrations of PKD small molecule inhibitor CRT0066101;

[0046] S105, the apoptosis rate of Cal-27 / PTX cells under the combined action of CRT0066101 and paclitaxel (PTX) was detected by flow cytometry.

[0047] The method for the establishment of human oral squamous cell carcinoma drug-resistant cell line Cal-27 / PTX, including:

[0048] Take the Cal-27 cells...

Embodiment 2

[0085] Take CRT0066101 and PTX, suitable filling agent, after mixing, prepare capsules.

Embodiment 3

[0087] Take CRT0066101 and PTX, appropriate fillers, binders, and lubricants to prepare granules.

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Abstract

The invention provides a composition. The composition comprises a protein kinase D inhibitor and an anti-cancer drug. Research finds that a combined treatment mode can improve the sensitivity and specificity to cancer treatment, provides a brand-new visual angle for clinical treatment and plays a more important role, so that the combined treatment mode has a wide application value.

Description

technical field [0001] The invention belongs to the technical field of oral squamous cell carcinoma treatment, and relates to the application of a PKD small molecule inhibitor in blocking the drug resistance of oral squamous cell carcinoma. Background technique [0002] Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors of the head and neck, accounting for more than 90%. There are about 500,000 new OSCC cases every year. In recent years, its incidence has increased year by year. increasing trend. In the past 30 years, the 5-year survival rate of advanced OSCC was only 40%-50%. [0003] Paclitaxel (PTX) is a cytotoxic agent that can stabilize tubulin and is widely used in the treatment of various tumors. PTX is different from traditional antitumor drugs. It interferes with the stability of tubulin, inhibits the division and proliferation of tumor cells, and plays an antitumor role. [0004] Tumor multi-drug resistance (MDR) refers to the phenome...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/337A61K31/55A61K31/517A61P35/00A61P1/02
CPCA61K45/06A61K31/337A61K31/55A61K31/517A61P35/00A61P1/02A61K2300/00
Inventor 陈娇陈红利崔博淼吕蝶康颖竹张平冯云
Owner SICHUAN UNIV
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