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A paper-based microfluidic chip and its application

A microfluidic chip and microfluidic technology, applied in the field of electrochemical analysis, can solve the problems of limited practical application, complicated electrode manufacturing process, and inability to mass produce, so as to shorten preprocessing time, avoid sensitivity reduction, and low cost Effect

Active Publication Date: 2022-04-19
CHINESE ACAD OF INSPECTION & QUARANTINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The latest research mainly focuses on the anti-pollution modification of the electrode surface, but the electrode manufacturing process is complicated and cannot be mass-produced, which limits its practical application

Method used

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  • A paper-based microfluidic chip and its application
  • A paper-based microfluidic chip and its application
  • A paper-based microfluidic chip and its application

Examples

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Embodiment Construction

[0033] like figure 1 As shown, a paper-based microfluidic chip includes a filter paper 1 on which a microfluidic pattern is printed. The microfluidic pattern includes a circular sample loading area 2 and a detection area 3, and a connecting channel is connected between the two 4 are connected, and ammonium sulfate solution is added dropwise in the sample loading area 2, wherein the sample loading area 2 and the detection area 3 are circles with a diameter of 10 mm, and the length of the connecting conduction 4 is 12 mm and the width is 6 mm.

[0034] In the present invention, a laser printer is used to print microfluidic patterns on filter paper 1, and heat-cure to form microfluidic channels, and then chemically modify the sample loading area 2 of the microfluidic device. Specifically include the following steps:

[0035] (1) Print the drawn microfluidic pattern on the filter paper 1 by using a laser printer;

[0036] (2) Put the printed filter paper 1 into an oven for therm...

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Abstract

The invention discloses a paper-based microfluidic chip, comprising a filter paper (1), on which a microfluidic pattern is printed, and the microfluidic pattern includes a circular sampling area (2) and the detection area (3), the two are connected through a connecting channel (4), and ammonium sulfate solution is added dropwise in the sample adding area (2). The invention also discloses a preparation method and application of the paper-based microfluidic chip. The paper-based microfluidic chip of the invention can be used for on-line pretreatment of urine samples and electrochemical detection of heavy metals in urine samples.

Description

technical field [0001] The invention relates to the field of electrochemical analysis, in particular to a paper-based microfluidic chip that can be used for online pretreatment of urine samples and a manufacturing method thereof. The chip can be used for electrochemical detection of heavy metals in urine samples. Background technique [0002] Electrochemical analysis is a portable, fast, low-cost and high-sensitivity analysis method, and has broad application prospects in the field of on-site instant detection. However, for biological sample detection, electrochemical sensors are easily contaminated by the matrix, affecting the sensitivity of the method. Therefore, it is necessary to cooperate with complex sample pretreatment procedures and rely on professional pretreatment equipment to complete the detection. This greatly limits the application of electrochemical methods in non-laboratory conditions. Paper-based microfluidic chip is a new type of miniaturized analysis sys...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00G01N27/30G01N27/48
CPCB01L3/5027G01N27/301G01N27/48B01L2200/10
Inventor 张庆王婉王志娟司念朋李海玉白桦
Owner CHINESE ACAD OF INSPECTION & QUARANTINE