Uveal melanoma metastasis risk prediction kit

A melanoma and risk prediction technology, applied in the field of disease molecular diagnostic kits, can solve problems such as unclear mechanism and relationship, and achieve the effect of predicting the risk of metastasis and excellent application prospects
CN112442536AActive Publication Date: 2021-03-05WEST CHINA HOSPITAL SICHUAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
WEST CHINA HOSPITAL SICHUAN UNIV
Publication Date
2021-03-05

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Abstract

The invention provides a novel uveal melanoma metastasis risk prediction kit, and belongs to the field of disease molecular diagnosis kits. According to the kit, a relationship between a p.E725K mutation site of an EZH2 gene and uveal melanoma metastasis is elaborated; and the novel kit is provided, wherein the kit realizes effective prediction of the uveal melanoma metastasis risk by virtue of detection of the p.E725K mutation site of the EZH2 gene, and the kit has a good application prospect.
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Description

technical field

[0001] The invention belongs to the field of disease molecular diagnosis kits. Background technique

[0002] Uveal melanoma (uveal melanoma, UM) is the most common primary intraocular malignant tumor in adults. . The degree of malignancy is high and the prognosis is poor. Not only can it lead to loss of vision, but also distant metastasis to the liver, lungs and other parts, which seriously threatens the life of the patient. The 10-year disease-related survival rate is only 50%.

[0003] In the past 30 years, the diagnosis and treatment of UM have made significant progress. The DecisionDx-UM test can classify UM patients into Class 1 (low risk of metastasis) and Class 2 (high risk of metastasis). The main treatment methods for UM are short-distance patch radiotherapy, laser therapy, local excision and enucleation, etc., but the 5-year survival rate of patients has not improved yet. The reason is that even if the local treatment is successful, 50% of the pa...

Claims

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