A kind of lactoferrin nanoparticle carrying rhein and its preparation method and use
A technology of lactoferrin and nanoparticles, which is applied in the field of lactoferrin nanoparticles loaded with rhein and its preparation, can solve the problems of low bioavailability, poor colon targeting ability, and low water solubility, and achieve rich sources, Improvement of colitis, the effect of simple preparation method
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[0070] Embodiment 1, the preparation of lactoferrin rhein nanoparticles of the present invention
[0071]Lactoferrin-rhein nanoparticles (rhein-loaded lactoferrin nanoparticles) were prepared by dialysis technology. Lactoferrin (LF) 50 mg was dissolved in 20 mL of deionized water to prepare an LF solution. Meanwhile, 5 mg of rhein (RH) was completely dissolved in 1 mL of DMSO to obtain an RH solution. The above RH solution was added dropwise to the LF solution under constant magnetic stirring. The mixture was then placed in an ice bath and sonicated using a probe sonicator (Sonicator XL, Misonix, Melville, NY, USA) at 50% amplitude power for 5 minutes to form an emulsion. Then, the emulsion was dialyzed against deionized water (molecular weight cut-off of 1000 Da) for 6 h to remove DMSO. Subsequently, it was filtered with a 0.45 μm filter to remove dust and free drug, and RH-NPs were obtained after filtration.
[0072] After that, 20 mg of hyaluronic acid (HA) was added to...
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