Unlock instant, AI-driven research and patent intelligence for your innovation.

Device for performing field asymmetric waveform ion mobility spectrometry

An asymmetric waveform and ion mobility spectrometry technology, which is applied in the field of field asymmetric waveform ion mobility spectrometry (FAIMS), can solve the problems of inability to achieve MS performance and limited customer acceptance

Pending Publication Date: 2021-03-19
SHIMADZU SEISAKUSHO CO LTD
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, customer acceptance has so far been limited, in large part because satisfactory MS performance without FAIMS separation cannot be achieved (i.e., cannot Satisfactory MS performance is obtained when the FAIMS unit of FAIMS / MS is operating in "transparent mode" with FAIMS separation off)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Device for performing field asymmetric waveform ion mobility spectrometry
  • Device for performing field asymmetric waveform ion mobility spectrometry
  • Device for performing field asymmetric waveform ion mobility spectrometry

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0151] Aspects and embodiments of the invention will now be discussed with reference to the drawings. Other aspects and embodiments will be apparent to those skilled in the art. All documents mentioned herein are hereby incorporated by reference.

[0152] In general, the present invention relates to possible structures of differential ion mobility spectrometers and their possible use in combination with mass spectrometers. A particular use is to improve the operation of low pressure DMS plants.

[0153] In general, the following examples can be considered to build on the teachings of ref [1] and contribute to the provision of FAIMS devices with segmented planar electrodes and improved separation and transparency modes.

[0154] the context

[0155] In designing the present invention, the inventors used the multipolar structures disclosed herein (in the form of electrode 26 in Fig. 2 of ref [1]) and the (non-segmented) planar structures (of ref [1] The form of the electro...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

An FAIMS device includes: a first segmented planar electrode segmented in a first plane and extending in a direction parallel to an analysis axis; a second segmented planar electrode segmented in a second plane and extending in a direction parallel to the analysis axis, the first and second segmented planar electrodes being separated from each other to provide an analysis gap; an advancing memberfor advancing ions through the analysis gap in a direction parallel to the analysis axis; and a power supply. The device operates in an FAIMS mode, the power supply applies a set of voltage waveformsto segments of the first and second segment planar electrodes to generate an asymmetric time-dependent electric field in the analysis gap for FAIMS analysis of ions; the set of voltage waveforms is such that the asymmetric time-dependent electric field has a curved isoelectric field intensity contour to focus the ions towards different spatial domains, and the device has a focus controller to allow a user to change the curvature of the isoelectric field intensity contour to change the focus intensity.

Description

technical field [0001] The present invention relates to apparatus for performing Field Asymmetric Waveform Ion Mobility Spectroscopy, or "FAIMS". Background technique [0002] Ion mobility spectroscopy ("IMS") is an analytical technique for separating ions in the gas phase based on their mobility in a carrier buffer gas. [0003] In linear IMS, ions are separated according to their absolute mobility K. [0004] In nonlinear IMS, ions are separated according to their response to a varying electric field. [0005] Field Asymmetric Waveform Ion Mobility Spectroscopy ("FAIMS") (see Ref. [3]), also known as Differential Mobility Spectroscopy ("DMS") (see Ref. [4]), is a (also known as "FAIMS gap") is an established nonlinear IMS method that separates ions by differences in mobility in a gas as a function of electric field strength. These differences depend on the geometry and physical and chemical properties of the ions and gas molecules, but are only weakly related to the ion...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/02H01J49/06H01J49/16G01N27/624
CPCH01J49/022H01J49/168H01J49/063H01J49/068G01N27/624
Inventor R·吉尔斯R·安德热耶夫斯基
Owner SHIMADZU SEISAKUSHO CO LTD