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Prevention or treatment method for peripheral neuropathy or pain accompanying disease in which peripheral neuropathy or astrocyte disorder is recognized

A technique for peripheral neuropathy and astrocytes, which is applied in the field of prevention or treatment of pain associated with peripheral neuropathy or diseases in which peripheral neuropathy or astrogliosis is confirmed, and can solve problems such as unidentified RGMa associations

Pending Publication Date: 2021-03-19
MITSUBISHI TANABE PHARMA CORP
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Thus, although a role for RGMa has been established in central nervous system injury, an association of RGMa has not been identified in peripheral neuropathy or pain symptoms associated with diseases in which peripheral neuropathy or astrocytopathy has been identified

Method used

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  • Prevention or treatment method for peripheral neuropathy or pain accompanying disease in which peripheral neuropathy or astrocyte disorder is recognized
  • Prevention or treatment method for peripheral neuropathy or pain accompanying disease in which peripheral neuropathy or astrocyte disorder is recognized
  • Prevention or treatment method for peripheral neuropathy or pain accompanying disease in which peripheral neuropathy or astrocyte disorder is recognized

Examples

Experimental program
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Effect test

Embodiment 1

[0203] Effects of anti-RGMa neutralizing antibody on pain and motor nerve conduction impairment in rat STZ-induced diabetic neuropathy model

[0204] This rat STZ-induced diabetic neuropathy model is a model for evaluating the effect on peripheral neuropathy, especially peripheral neuropathy in diabetic neuropathy. In addition, this model is a model that can also evaluate the effect on pain symptoms of peripheral neuropathy, especially diabetic neuropathy, and the effect on pain symptoms caused by diseases in which astrocytic lesions are confirmed.

[0205] (1-1) Establishment of STZ-induced diabetic neuropathy model in rats

[0206] SD male rats were used in the experiments. Intravenous administration of STZ (streptozotocin) (60 mg / kg) dissolved in 0.75 mM citrate buffer (pH 4.5) at a concentration of 30% to rat tail veins, after 3 weeks, the blood sugar level reached 300 mg / dl The above rats were used as the STZ experimental group (diabetic group). For the normal group, S...

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Abstract

The present invention addresses the problem of providing a novel prevention or treatment method for peripheral neuropathy, or a prevention or treatment method for pain symptoms due to a disease in which peripheral neuropathy or an astrocyte disorder is recognized. The present invention further provides a prevention or treatment agent for peripheral neuropathy, or pain symptoms due to peripheral neuropathy or a disease in which peripheral neuropathy or an astrocyte disorder is recognized, said agent containing an RGM-inhibiting substance.

Description

technical field [0001] The present invention relates to a prophylactic or therapeutic agent for peripheral neuropathy characterized by inhibition of RGMa activity, or pain associated with a disease in which peripheral neuropathy or astrocytopathy is confirmed, and a prophylactic or therapeutic method using the same. Background technique [0002] Astrocytes are a type of glial cells that exist in the central nervous system, and have the following functions: (1) support the function of the neuron network structurally, (2) mediate the transport of substances Function to regulate various conditions around astrocytes, (3) 1 synaptic function performed by 3 cells through close relationship between pre-synapse, post-synapse, and glial cells, (4) Regulating the concentration of extracellular ions, (5) buffering at the energy level, and (6) promoting the myelination activity of oligodendrocytes, etc. The functions of astrocytes as described above are attracting attention in various ...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K39/395A61P25/02A61P27/02
CPCA61P25/02A61P27/02C07K16/22C07K2317/76A61K2039/505Y02A50/30A61K39/395A61K45/00C07K2317/24C07K2317/565C07K16/2866
Inventor 石田勇人石田裕一M·乔瑟夫·帕伦堡佐佐木淳
Owner MITSUBISHI TANABE PHARMA CORP
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