Lipid-lowering traditional Chinese medicine monomer composition, preparation and use

A technology of monomer composition and traditional Chinese medicine preparation, which is applied in the direction of drug combination, medical preparations containing active ingredients, and pharmaceutical formulas. Excellent lipid effect, drug safety, blood lipid lowering effect

Active Publication Date: 2021-08-31
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The water pill is small in size, easy to swallow, and not easy to absorb moisture, but it still cannot solve the problem that the effect of reducing hyperlipidemia is not obvious and the oral dose is large
[0008] In summary, although the western medicine lipid-lowering drug simvastatin has a good lipid-lowering effect, it has obvious side effects and is not suitable for patients to take for a long time
Although the Chinese patent medicine lipid-lowering drug Jiangzhining granule and its improved dosage form have few side effects in the treatment of hyperlipidemia and are suitable for long-term consumption, there are problems such as large dosage and ineffective blood lipid-lowering effect.

Method used

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  • Lipid-lowering traditional Chinese medicine monomer composition, preparation and use
  • Lipid-lowering traditional Chinese medicine monomer composition, preparation and use
  • Lipid-lowering traditional Chinese medicine monomer composition, preparation and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] The lipid-lowering traditional Chinese medicine monomer composition in this example consists of quercetin-3-O-β-D-glucuronide, hyperin, Composition of rubyfusarmycin gentiobioside, emodin-8-O-β-D-glucoside, O-nornuciferine and apricot papaverine.

Embodiment 2

[0056] The lipid-lowering traditional Chinese medicine monomer composition in this example consists of quercetin-3-O-β-D-glucuronide, hyperin, Composition of rubyfusarmycin gentiobioside, emodin-8-O-β-D-glucoside, O-nornuciferine and apricot papaverine.

Embodiment 3

[0058] The lipid-lowering traditional Chinese medicine monomer composition in this example consists of quercetin-3-O-β-D-glucuronide, hyperin, Composition of rubyfusarmycin gentiobioside, emodin-8-O-β-D-glucoside, O-nornuciferine and apricot papaverine.

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Abstract

The invention discloses a lipid-lowering traditional Chinese medicine monomer composition, preparation and application. The lipid-lowering traditional Chinese medicine monomer composition consists of quercetin-3-O-β-D-glucuronic acid with a mass ratio of 9.1-9.6:1:4.2-4.7:1.6-2.1:2.2-2.7:1.7-2.2 glycoside, hyperoside, rubafasarin gentiobioside, emodin‑8‑O‑β‑D‑glucoside, O‑nornuciferine and apricot papaverine. The traditional Chinese medicine monomer composition of the invention can lower blood lipids, especially for hypertriglyceridemia, and the lipid-lowering effect is better than that of the existing commonly used Chinese patent medicine lipid-lowering drug Jiangzhining Granules.

Description

technical field [0001] The invention relates to a lipid-lowering traditional Chinese medicine monomer composition, preparation and application. Background technique [0002] Hyperlipidemia is a common disease in today's society. It is manifested as high serum cholesterol and triglycerides, which can directly cause some diseases that seriously endanger human health, such as atherosclerosis, coronary heart disease, pancreatitis, etc. The incidence of hyperlipidemia is increasing year by year. Among the adults over 30 years old in the country, the incidence of hyperlipidemia is 10% to 20%. [0003] At present, there are many blood lipid-lowering drugs on the market. Western medicines are mostly Western medicines because of their fast onset of action and certain curative effect. Commonly used drugs such as simvastatin can be used to reduce elevated total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B and triglycerides, but its side effects are obvious, which...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/704A61K31/472A61K31/473A61P3/06
CPCA61K31/472A61K31/473A61K31/704A61K31/7048A61P3/06A61K2300/00
Inventor 姜艳艳刘斌张榆李丽华
Owner BEIJING UNIV OF CHINESE MEDICINE
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