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Microfluidic platform, preparation method and application thereof

A microfluidic and platform technology, applied in biochemical equipment and methods, enzymology/microbiology devices, bioreactor/fermenter combinations, etc., can solve the problem of axon formation and growth under barriers of different lengths that cannot be obtained at the same time, The channel barrier has a single structure and a fixed length

Active Publication Date: 2021-04-16
BEIJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the channel barrier structure of the current microfluidic platform is single and the length is fixed, so the formation and growth of axons under barriers of different lengths cannot be obtained at the same time.

Method used

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  • Microfluidic platform, preparation method and application thereof
  • Microfluidic platform, preparation method and application thereof
  • Microfluidic platform, preparation method and application thereof

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Embodiment Construction

[0029] Specific embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0030] figure 1 is a schematic diagram of the microfluidic platform of the present invention, such as figure 1 As shown, the microfluidic platform includes a plurality of culture chambers 2, and the culture chambers are connected by a microchannel 1, and the depth of the microchannel 1 is determined by the axons of cells or tissues in the culture chamber, so that the axons pass through the In the microchannel, the cells and tissues corresponding to the axons cannot pass through the microchannel, and the cells or tissues in different culture chambers 2 are connected through the axons.

[0031] In one embodiment, the side of the culture chamber communicating with the microchannel is curved, so that the lengths of the microchannels between the culture chambers are different.

[0032] The above-mentioned microfluidic platform can physically isol...

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Abstract

The invention provides a microfluidic platform, a preparation method and application thereof. The microfluidic platform comprises a plurality of culture chambers, the culture chambers are connected through micro-channels, the depth of the micro-channels is determined through axons of cells or tissue in the culture chambers, so that the axons pass through the micro-channels, and the cells and tissues corresponding to the axons cannot pass through the micro-channels; and the cells or tissues in different culture chambers are connected through axons. According to the invention, physical and fluid isolation is carried out on damaged nerve cells or tissues to realize co-culture.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, and more specifically, to a microfluidic platform, a preparation method and an application thereof. Background technique [0002] The central nervous system is an important part of the human nervous system. It is responsible for receiving and transmitting information from all parts of the body, integrating and processing it, sending it out, or storing it in the central nervous system to become the neural basis of learning and memory. The central nervous system has structural fragility and functional complexity, so its damage will cause serious functional damage and obstacles, affect the quality of life of patients, and bring huge economic burdens to patients and society. Central nervous system injuries are mostly caused by traumatic events. The repair and regeneration of the central nervous system are affected by glial scars, different physiological activities, and complex metabolites...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/00C12M1/00
Inventor 李倩陈涛
Owner BEIJING UNIV OF TECH
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