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Traditional Chinese medicine composition for treating type 2 diabetes mellitus insulin resistance

A technology for insulin resistance and type 2 diabetes, applied in drug combinations, metabolic diseases, pharmaceutical formulations, etc., can solve problems such as low success rate, difficulty in explaining, and high cost

Active Publication Date: 2021-04-30
SHANDONG ACAD OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] With the rapid development of modern medical technology, the linear model of "single gene-single target-single disease" followed by traditional research and development has encountered huge bottlenecks and severe challenges. The cost is increasing and the success rate is getting lower and lower. Not only in Research on complex diseases and their medicines has encountered bottlenecks, and it is also difficult to explain the scientific connotation of traditional Chinese medicine that is clinically effective

Method used

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  • Traditional Chinese medicine composition for treating type 2 diabetes mellitus insulin resistance
  • Traditional Chinese medicine composition for treating type 2 diabetes mellitus insulin resistance
  • Traditional Chinese medicine composition for treating type 2 diabetes mellitus insulin resistance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Preparation of dripping pills for preventing and treating type 2 diabetes mellitus insulin resistance:

[0057] Take 80g of kaempferol, 120g of hesperidin, 160g of naringin, 90g of apigenin, and 500g of polyethylene glycol, heat to melt, mix well, move to the liquid container of the dropping pill machine, keep warm at 90°C, drop into the cooling In the simethicone oil, make 1000g drop pill, get final product. Example 2

Embodiment 2

[0058] Preparation of Insulin Resistance Injection for Prevention and Treatment of Type 2 Diabetes Mellitus:

[0059] Take 100g of kaempferol, 90g of hesperidin, 150g of naringin, and 60g of apigenin, add 1800ml of water for injection, stir to dissolve, adjust the pH value to 7.0-7.5 with saturated sodium hydroxide solution, add 10g of activated carbon for needles, and add Water for injection to 2000ml, mix well, boil for 30 minutes, refrigerate, filter, add water for injection to 5000ml, filter with 0.45μm and 0.22μm microporous membranes respectively, pack in 5ml each, fill with nitrogen, seal and circulate Steam sterilize for 30 minutes to obtain 1000 concentrated solution for injection.

Embodiment 3

[0061] Preparation of capsules for preventing and treating type 2 diabetes insulin resistance:

[0062] Take 130g of kaempferol, 180g of hesperidin, 90g of naringin, and 110g of apigenin, add appropriate amount of starch, mix well, pack in capsules, and make 1000 capsules, and you get it.

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Abstract

The invention belongs to the field of traditional Chinese medicine research and development, and particularly relates to a pharmaceutical composition for treating insulin resistance of type 2 diabetes mellitus. The pharmaceutical composition comprises the following components in parts by weight: 2 to 8 parts of kaempferol; 3 to 12 parts of hesperidin; 4 to 16 parts of naringin; and 3.5 to 14 parts of apigenin. The insulin resistance titer of the pharmaceutical composition for treating type 2 diabetes mellitus can reach 98.58%. The pharmaceutical composition disclosed by the invention does not contain toxic components such as calcium oxalate needle crystals and lectin proteins of pinellia ternate, so the harm of inflammatory action and irritating action of the original formula of the gallbladder-warming decoction on a human body is avoided, the pharmaceutical composition can be used trustingly, and the curative effect is enhanced; finally, a foundation is laid for further developing a novel active ingredient composition preparation.

Description

technical field [0001] The invention belongs to the field of research and development of traditional Chinese medicines, and in particular relates to a pharmaceutical composition for treating insulin resistance of type 2 diabetes. Background technique [0002] The prevention and treatment of type 2 diabetes has been a research hotspot in recent years. Type 2 diabetes accounts for more than 90% of diabetic patients. Unlike type 1 diabetes, in which the body has lost the ability to produce insulin, people with type 2 diabetes still produce insulin but cannot use it effectively (medically known as "insulin resistance"). Insulin resistance is a common risk factor for type 2 diabetes and various cardiovascular diseases. Therefore, in the process of diabetes treatment, in addition to sufficient protection of cell function, attention must also be paid to the improvement of insulin resistance. Only by starting from both aspects at the same time can the occurrence and development of...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/352A61P3/10A61P5/50
CPCA61K31/7048A61K31/352A61P3/10A61P5/50A61K2300/00
Inventor 徐男王淑玲
Owner SHANDONG ACAD OF CHINESE MEDICINE
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