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A kind of hemostatic compound dressing for medical trauma

A wound, composite polymer technology, applied in the field of medical supplies, can solve the problems of no antibacterial wound promoting healing, limiting the effective use of dressings, and adhesion of dressings to wounds, etc. The effect of fast hemostasis

Active Publication Date: 2022-06-24
HENAN YADU IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The skin provides protection for the human body. Once the skin is injured, it will have a great impact on body functions; therefore, after the skin is injured, it is necessary to protect the wound in time to avoid infection of the wound; medical dressings are used as a temporary treatment for wounds. Medical materials, its main function is to control wound exudate, accelerate wound hemostasis, protect the wound surface from bacterial and dust contamination of the wound, and promote wound healing; currently commonly used wound repair supplies include natural fiber dressings (gauze), synthetic fiber dressings , gel dressing and sponge dressing; natural cellulose such as gauze mainly acts as a physical barrier to the wound, does not have antibacterial and wound healing effects, and has poor affinity with the wound; synthetic fiber dressing Usually prepared from biopolymer materials, it has good affinity with the wound, but its permeability is high, and it is easy to cause the dressing to adhere to the wound when it is peeled off from the wound, and it is not easy to remove from the wound surface; gel dressing , is to form a gel through the dressing to absorb the wound exudate; this kind of dressing will have a colloid layer with a network structure formed after the surface dressing first contacts the wound to absorb liquid, which hinders the inner dressing from further absorbing liquid. This prevents the "fish-eye" phenomenon of the gel dressing; limits the effective utilization of the dressing;

Method used

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  • A kind of hemostatic compound dressing for medical trauma
  • A kind of hemostatic compound dressing for medical trauma
  • A kind of hemostatic compound dressing for medical trauma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation of Dandelion Fluff / Viscose Nonwoven:

[0032] (1) After collecting 500g of dandelion fluff and carrying out ultrasonic activation treatment in 0.5mol / L sodium bicarbonate solution, wash until the washing liquid is neutral, and obtain activated dandelion fluff after drying;

[0033] (2) opening the activated dandelion fluff fiber (PR) and viscose fiber (VF);

[0034] (3) short fibers with uniform distribution of warp and weft are formed after carding by the fiber carding machine after opening;

[0035] (4) laying the short fibers into a fiber web through a web spreader;

[0036] (5) put the fiber web into the spunlace machine for spunlace composite 2-4 times on both sides; make dandelion fiber and viscose fiber entangle together to obtain dandelion fluff / viscose fiber non-woven base material; wherein, The pressure of spunlace is 2-3MPa, and the feeding and discharging speed is 14-16m / min;

[0037] The viscose fiber is prepared by melt spinning with crop st...

Embodiment 2

[0044] Investigation of the amount of gluten protein added:

[0045] Add gluten protein to 1000g 1wt% sodium alginate aqueous solution under stirring conditions (0.1g / part), and with the increase of the number of gluten protein added, the viscosity of the sol gradually increases. When the amount of gluten protein added is greater than 10 When the gluten protein is not completely dissolved and reacted, the formed sol is uneven, and there is unreacted gluten protein powder in the sol; the present invention selects that the addition ratio of gluten protein and oxidized sodium alginate is less than 1:10, preferably 0.5-1 : 10.

[0046] Preparation of composite biopolymer sol solution:

[0047] Take 0.5g of gluten protein and add it to 1000g of 1wt% sodium alginate oxidized aqueous solution at 30-40°C and stir at 250r / min to complete the reaction, then add 125mL of 4wt% chitosan acetic acid solution (1wt% degree of deacetylation, 85% chitosan and 3wt% chitosan). % carboxymethyl c...

Embodiment 3

[0061] Preparation of medical trauma hemostasis composite dressing:

[0062] Using the non-woven fabrics J-1 to J-12 prepared in Example 1 as the base material, the composite biopolymer sol R-2 prepared in Example 2 was coated on its surface, and taken out after being evacuated in a vacuum device , under a three-stage roller press at 50-60 ° C for hot rolling, drying and sterilization to obtain a medical hemostatic composite dressing; in turn recorded as RJ-12, RJ-22, RJ-32, RJ-42, RJ-52, RJ-62, RJ-72, RJ-82, RJ-92, RJ-102, RJ-112, RJ-122;

[0063] The performance of the above medical hemostatic composite dressing was tested, and the results are shown in Table 3.

[0064] table 3.

[0065]

[0066] It can be seen from the data in Table 3 that with the increase of the dandelion fluff content in the non-woven substrate, the breaking strength of the dressing shows a decreasing trend, the air permeability first increases and then decreases, and the liquid absorption rate decr...

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Abstract

The invention discloses a hemostatic composite dressing for medical trauma. The invention uses dandelion fluff / viscose fiber non-woven fabric as a base material, and uses a vacuuming method to fill gluten protein, oxidized sodium alginate, and chitosan composite polymer materials. A medical wound hemostatic composite dressing with high water absorption, good air permeability and antibacterial properties is obtained between the fibers and the surface of the non-woven fabric. The dressing not only has good mechanical strength, but also has anti-adhesion, fast hemostasis and wound healing effects , shorten the wound healing time.

Description

technical field [0001] The invention belongs to the field of medical supplies, in particular to a medical trauma hemostasis composite dressing. Background technique [0002] The skin provides protection for the human body. Once the skin is injured, it will have a great impact on bodily functions. Therefore, after the skin is injured, the wound needs to be protected in time to avoid infection. Medical materials, whose main function is to control the exudate of the wound, accelerate wound hemostasis, protect the wound surface to prevent bacteria and fine dust from contaminating the wound, and promote wound healing; currently commonly used wound repair products include natural fiber dressings (gauze), synthetic fiber dressings , gel dressings and sponge dressings; natural cellulose such as gauze mainly acts as a physical barrier to the wound, does not have antibacterial and wound healing effects, and has poor affinity with the wound; synthetic fiber dressings It is usually pre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/40A61L15/28A61L15/32A61L15/44A61L24/00A61L24/08A61L24/10D04H1/4382D04H1/492
CPCA61L15/40A61L15/32A61L15/28A61L15/44A61L24/0015A61L24/0005A61L24/08A61L24/108D04H1/4382D04H1/492A61L2300/252A61L2300/232A61L2300/418A61L2300/412C08L89/00C08L5/04C08L5/08
Inventor 张正男段书霞潘红福闫钧付迎坤常聪周静储旭何孜翰周小婷刘康博林建香
Owner HENAN YADU IND
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