Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition for reducing blood sugar as well as preparation method and application of pharmaceutical composition

A composition and blood sugar-lowering technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., to achieve the effects of promoting hematopoietic function, anti-inflammatory and anti-tumor immunity, and regulating gastric contraction

Active Publication Date: 2021-05-07
ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
View PDF6 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no research on the effect of four medicinal and food homologous mixed polysaccharides, Polygonatum polysaccharide, Lycium barbarum polysaccharide, Codonopsis polysaccharide and Jujube polysaccharide, on lowering blood sugar.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition for reducing blood sugar as well as preparation method and application of pharmaceutical composition
  • Pharmaceutical composition for reducing blood sugar as well as preparation method and application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 polysaccharide extraction

[0025] Polygonatum multiflora, Lycium barbarum, Codonopsis pilosula, and jujube are extracted with the same method to extract polysaccharides. The specific extraction method is as follows:

[0026] (1) Drying: medicinal materials are dried in an oven at 55°C until the water content does not exceed 10%.

[0027] (2) Pulverization: take the dried medicinal material raw material, pulverize and pass through a No. 4 sieve.

[0028] (3) Degreasing and impurity removal: Add 10 times the amount of petroleum ether (boiling range 60-90°C) to the medicinal material powder, shake well, reflux in a water bath at 75°C for 2 hours, suction filter to recover petroleum ether, and evaporate the residue in the filter cake at the same time petroleum ether. After adding 10 times the amount of 95% ethanol solution to the filter cake to reflux for extraction for 1.5 h, the filter residue was collected by suction filtration and dried in an oven at 55°...

Embodiment 2 4

[0033] The hypoglycemic effect of embodiment 2 four kinds of medical material polysaccharides

[0034] (1) Grouping: 200 experimental mice were equally divided into normal group, control group and model group 1-18, with 10 mice in each group.

[0035] (2) Induced model: use drugs to induce mice in the control group and model group 1-18 into a diabetic mouse model, and measure the blood glucose of the mice by taking blood from the tip of the tail and using blood glucose test paper to determine whether the diabetic mouse model is successfully established. The specific method is as follows: after the mice were fasted overnight, the STZ solution (50 mg / kg, STZ dissolved in citric acid buffer, pH 4.2) was intraperitoneally injected the next day. After continuous injection for 5 days, the blood glucose changes of the mice were monitored. After 7 days, the mice with blood glucose concentration ≥ 16.7mmol / L were successfully modeled.

[0036] (3) All mice were given intragastric adm...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
water contentaaaaaaaaaa
Login to View More

Abstract

The invention discloses a pharmaceutical composition for reducing blood sugar as well as a preparation method and application of the pharmaceutical composition, and belongs to the field of medicines and health-care products. According to the pharmaceutical composition for reducing blood sugar, disclosed by the invention, the molar mass ratio of polygonatum cyrtonema Hua polysaccharide, to lycium polysaccharide, to codonopsis pilosula polysaccharide to ziziphus jujuba polysaccharide is (1-2): (1-2): (1-2): 1. According to the invention, the hypoglycemic effect of the mixed polysaccharide of the four medicinal and edible medicinal materials, namely polygonatum cyrtonema Hua, lycium, codonopsis pilosula and ziziphus jujube, is better than that of a single polysaccharide, so that a new product can be developed, the four medicinal material resources can be fully utilized, and besides, more consumers can be benefited.

Description

technical field [0001] The invention relates to the fields of medicine and health products, in particular to a pharmaceutical composition for lowering blood sugar, a preparation method and an application. Background technique [0002] Polygonatum cyrtonema Hua (Polygonatum cyrtonema Hua) is a perennial herb of the genus Polygonatum in the family Liliaceae. The medicinal parts are rhizomes, sweet and flat in taste. Tonify qi and nourish yin, invigorate the spleen, moisten the lungs, and benefit the kidneys. For deficiency of the spleen and weak stomach, fatigue and fatigue, dry mouth and lack of food, dry cough due to lung deficiency, deficiency of essence and blood, internal heat and thirst. Lycium (Lycium) is a plant of Solanaceae and Lycium genus. The medicinal part is the fruit, which is sweet and flat. For nourishing the liver, nourishing the kidney, moistening the lung. Codonopsis pilosula (Franch.) Nannf. Codonopsis pilosula (Franch.) Nannf.) Codonopsis pilosula is ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P3/10A61K36/8969A61K36/815A61K36/344A61K36/725C08B37/00
CPCA61K31/715A61P3/10A61K36/8969A61K36/815A61K36/344A61K36/725C08B37/0003A61K2300/00
Inventor 俞年军徐君周安程鹤邢丽花吴振东韩荣春
Owner ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com