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Application of bicyclic alcohol compound in preparation of medicine for preventing or treating atherosclerosis and pharmaceutical composition

A technology of atherosclerosis and bicyclol, which is applied in drug combinations, active ingredients of heterocyclic compounds, cardiovascular system diseases, etc., can solve problems such as undiscovered and undiscovered treatment of bicyclol atherosclerosis, and achieve fat reduction Accumulation, increasing clinical application value, high clinical safety effect

Pending Publication Date: 2021-05-07
BEIJING UNION PHARMA FACTORY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The present inventor has not found that bicyclol is used for the treatment of atherosclerosis through domestic and foreign patent literature retrieval and published journal paper retrieval, and has not found any reports or documents related to the present invention.

Method used

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  • Application of bicyclic alcohol compound in preparation of medicine for preventing or treating atherosclerosis and pharmaceutical composition
  • Application of bicyclic alcohol compound in preparation of medicine for preventing or treating atherosclerosis and pharmaceutical composition
  • Application of bicyclic alcohol compound in preparation of medicine for preventing or treating atherosclerosis and pharmaceutical composition

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Experimental program
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Embodiment 1

[0066] 1. Experimental design:

[0067]Bicyclol was provided by Beijing Union Pharmaceutical Factory, Institute of Materia Medica, Chinese Academy of Medical Sciences, product batch number 150643H.

[0068] Clean-grade ApoE (- / -) mice (male, 6 weeks old, weighing 20-22 g) were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. The animals were kept in the Animal Center of the Institute of Materia Medica, Chinese Academy of Medical Sciences. The feeding environment was a constant temperature of 23±2°C and a moderate temperature of 50-70%. The sterile bedding was changed twice a week, and free access to food and water.

[0069] The administration and treatment of the animals are as follows: ApoE (- / -) mice were acclimatized in the animal room for a week, and the animals were divided into a normal diet group (8 animals), a high-fat diet group (8 animals), and a low-dose bicyclol group. group (100mg / kg / day) and high-dose bicyclol group (200mg / kg / day), t...

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Abstract

The invention relates to application of a bicyclic alcohol compound in preparation of a medicine for preventing or treating atherosclerosis and a pharmaceutical composition containing the bicyclic alcohol compound. The invention discovers a new application of a common liver-protecting medicine bicyclic alcohol, namely a new application of a medicine for treating atherosclerosis by using bicyclic alcohol, or provides a new treatment indication of bicyclic alcohol.

Description

technical field [0001] The invention relates to the application of bicyclic alcohol compounds in the preparation of medicines for preventing or treating atherosclerotic diseases and a composition containing them, belonging to the field of biopharmaceuticals. Background technique [0002] Cardiovascular disease is the main cause of mortality and disability worldwide [1]. The mortality rate of cardiovascular disease in my country has been ranked first for many years, higher than that of tumors and other diseases, and the prevalence rate is still on the rise. According to According to statistics, there are 230 million patients with cardiovascular diseases in my country. If the corresponding basic research and clinical treatment are not improved, it is estimated that the risk of cardiovascular diseases in my country will increase by 50% by 2030. Atherosclerosis (AS), as the pathological basis of most cardiovascular diseases such as stroke, myocardial infarction and heart failure,...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/36A61P9/10
CPCA61K45/06A61K31/36A61P9/10
Inventor 王璐璐蒋建东李阳尤峰郭慧慧
Owner BEIJING UNION PHARMA FACTORY
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