Application of bicyclic alcohol compound in preparation of medicine for preventing or treating atherosclerosis and pharmaceutical composition
A technology of atherosclerosis and bicyclol, which is applied in drug combinations, active ingredients of heterocyclic compounds, cardiovascular system diseases, etc., can solve problems such as undiscovered and undiscovered treatment of bicyclol atherosclerosis, and achieve fat reduction Accumulation, increasing clinical application value, high clinical safety effect
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[0066] 1. Experimental design:
[0067]Bicyclol was provided by Beijing Union Pharmaceutical Factory, Institute of Materia Medica, Chinese Academy of Medical Sciences, product batch number 150643H.
[0068] Clean-grade ApoE (- / -) mice (male, 6 weeks old, weighing 20-22 g) were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. The animals were kept in the Animal Center of the Institute of Materia Medica, Chinese Academy of Medical Sciences. The feeding environment was a constant temperature of 23±2°C and a moderate temperature of 50-70%. The sterile bedding was changed twice a week, and free access to food and water.
[0069] The administration and treatment of the animals are as follows: ApoE (- / -) mice were acclimatized in the animal room for a week, and the animals were divided into a normal diet group (8 animals), a high-fat diet group (8 animals), and a low-dose bicyclol group. group (100mg / kg / day) and high-dose bicyclol group (200mg / kg / day), t...
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