A kind of synthetic method of perfluoroalkyl substituted polycyclic quinazolinone derivatives

A polycyclic quinazolinone and perfluoroalkyl technology, which is applied in the field of synthesis of polycyclic quinazolinone derivatives, can solve the problems of harsh conditions, difficult preparation and the like, and achieves reaction safety, easy operation, and reaction selection. good effect

Active Publication Date: 2022-03-01
ZHEJIANG UNIV OF TECH
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inventive technology disclosed in this patent still has defects such as harsh conditions, the need for metal participation and difficult preparation of substrates.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of synthetic method of perfluoroalkyl substituted polycyclic quinazolinone derivatives
  • A kind of synthetic method of perfluoroalkyl substituted polycyclic quinazolinone derivatives

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Add 3-(pent-4-en-1-yl)quinazolinone (0.2mmol, 43mg), sodium trifluoromethanesulfinate (0.6mmol, 94mg) into a 10mL solvent storage bottle, add DMSO (2.0mL ) as a solvent, the reaction was carried out under open conditions, irradiated with 10w of visible light with a wavelength of 410-415nm and reacted at a temperature of 25°C for 8h. After the reaction, the reaction system was washed with water and extracted with dichloromethane, then separated into an organic layer and an aqueous layer. After the organic layer was dried with anhydrous sodium sulfate, it was evaporated and concentrated under reduced pressure to remove the solvent to obtain a yellow oil. The yellow oil was separated by column chromatography, using a mixture of petroleum ether and ethyl acetate with a volume ratio of 15:1 as the eluent, collecting the eluate containing the target compound, distilling off the solvent and drying to obtain 41 mg of white solid 6-( 2,2,2-trifluoroethyl)-8,9-dihydro-6hydro-pyri...

Embodiment 2

[0024] The experimental method of Example 2 was repeated in Example 1, except that "the solvent in the system was replaced with water (2ml)", and other operations were the same as in Example 1 to obtain 28 mg of white solid 6-(2,2,2- Trifluoroethyl)-8,9-dihydro-6hydro-pyrido[2,1-b]quinazolin-11(7hydrogen)-one, yield 50%.

Embodiment 3

[0026] The experimental method of embodiment 3 repeats embodiment 1, and difference is only " change sodium trifluoromethanesulfinate dosage into 0.4mmol ", other operations are the same as embodiment 1, obtain 38mg white solid 6-(2,2 ,2-trifluoroethyl)-8,9-dihydro-6hydro-pyrido[2,1-b]quinazolin-11(7hydrogen)-one, the yield was 67%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
wavelengthaaaaaaaaaa
wavelengthaaaaaaaaaa
Login to view more

Abstract

The invention discloses a method for synthesizing perfluoroalkyl-substituted polycyclic quinazolinone derivatives, which combines the quinazolinone derivatives containing inactive double bonds represented by formula (I), and the quinazolinone derivatives represented by formula (II The sodium perfluoroalkyl sulfinate shown in ) is dissolved in a solvent, and the reaction is carried out under open conditions. Under the irradiation of visible light, the reaction is carried out at room temperature for 3‑24 h. After the reaction is completed, the reaction system is post-treated to obtain the formula ( III) Perfluoroalkyl substituted polycyclic quinazolinone derivatives; the reaction equation is as follows: the present invention uses light as a reaction energy source, and realizes quinazolinone containing inactive double bonds without any additives. The perfluoroalkylation / cyclization reaction of oxazolinones has the advantages of safe process, low cost and simple operation, and provides a green synthesis method of perfluoroalkyl-substituted polycyclic quinazolinone derivatives.

Description

technical field [0001] The invention relates to a method for synthesizing perfluoroalkyl-substituted polycyclic quinazolinone derivatives. Background technique [0002] The quinazolinone structure is a commonly used pharmacophore in the field of drug design. Studies have confirmed that derivatives containing the core of this structure have various pharmacological activities, including the treatment of diseases such as inflammation, infection, bronchitis and asthma. As potential lead compounds, quinazolinone structures have broad research prospects in the field of new drug development. In recent years, some progress has been made in the synthesis of polycyclic quinazolinone derivatives, mainly including: (1) by the cyclization reaction (A.Kamal, K.V.Ramana and M.V.Rao, J. Org. Chem. 2001, 66, 997; C. Gil and S. Chem. Eur. J., 2005, 11, 2680; A. Kamal, N. Markandeya, N. Shankaraiah, C. R. Reddy, S. Prabhakar, C. S. Reddy, M. N. Eberlin and L. S. Santos, Chem. Eur. J., 2009,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): C07D471/04C07D487/04
CPCC07D471/04C07D487/04
Inventor 金灿孙彬黄盼怡
Owner ZHEJIANG UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap