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A biomarker for predicting or detecting acute leukemia

A technology for acute leukemia and Raman spectrum detection, which is applied in the field of disease detection to achieve the effect of reducing costs and shortening detection time

Active Publication Date: 2022-05-06
INST OF HEMATOLOGY & BLOOD DISEASES HOSPITAL CHINESE ACADEMY OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE
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Problems solved by technology

In contrast, no work has been reported to systematically study the Raman spectroscopic features of ALs and AML subtypes based on bone marrow supernatants

Method used

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  • A biomarker for predicting or detecting acute leukemia
  • A biomarker for predicting or detecting acute leukemia
  • A biomarker for predicting or detecting acute leukemia

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Embodiment Construction

[0033] The present invention will be further described below in conjunction with specific examples, but the protection scope of the present invention will not be limited.

[0034] 1. Sample Collection

[0035] Patients with acute cell leukemia in the Hematology Hospital of the Chinese Academy of Medical Sciences (Institute of Hematology, Chinese Academy of Medical Sciences) in 2016 were selected, mainly patients who were hospitalized in our hospital from January 2016 to June 2016, including 48 males and 35 females , the youngest is 1 year old and the oldest is 67 years old. All cases underwent bone marrow aspiration for bone marrow cell morphology, flow cytometry, histocytochemistry, chromosomes, fusion genes, and electron microscopy. Clinically, the diagnosis was based on cell morphology and histocytochemistry, combined with other examinations, and confirmed by FAB . Among them, there were 22 patients with ALL, 61 patients with AML, including 19 patients with AML-M2, 12 pat...

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Abstract

The present invention relates to a biomarker for predicting or detecting acute leukemia, specifically, the present invention relates to the detection of 1443 cm in bone marrow supernatant based on Raman spectroscopy ‑1 (protein and / or lipid / cholesterol), 1437cm ‑1 (lipid / cholesterol), 1579cm ‑1 The application of the level of peak position intensity (hemoglobin and / or nucleic acid) as a biomarker in the preparation of a product for predicting or detecting acute leukemia. The invention screens the specific and significant Raman shift as the biomarker of ALs, and lays the foundation for better use of clinical biochemical data in the diagnosis and treatment of acute leukemia.

Description

technical field [0001] The invention relates to the field of disease detection, in particular to a biomarker for predicting or detecting acute leukemia. Background technique [0002] Acute leukemia (ALs) is a malignant clonal disease derived from hematopoietic stem cells. According to cell morphology, it can be divided into two categories: acute myeloid leukemia and acute lymphoblastic leukemia, and each category is divided into several subtypes. Acute myeloid leukemia (AML) is the most common leukemia in adults, which is the result of abnormal proliferation and differentiation of hematopoietic cells in the bone marrow. AML is classified into 7 types such as AML-M1 by the FAB Blood Disease Cooperative Group. Acute Lymphoblastic Leukemia (ALL) can be seen in both children and adults, but its incidence is higher between the ages of 2 and 5. The diagnosis of ALs is mainly based on clinical symptoms, peripheral blood pictures, and bone marrow aspiration blood tests. Further t...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65G01N33/574
CPCG01N21/65G01N33/57426G01N33/57488
Inventor 梁昊岳高瀛岱程雪莲茹永新董树旭
Owner INST OF HEMATOLOGY & BLOOD DISEASES HOSPITAL CHINESE ACADEMY OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE