Drug metabolic enzyme and drug action target gene detection method and device and storage medium

Abstract

The invention discloses a drug metabolic enzyme and drug action target gene detection method. The method comprises the following steps: a genotype distinguishing step: distinguishing SNP genotypes of different sites according to PCR fluorescence signals of a target gene in a sample to be detected; a genotype interpretation step: interpreting SNP genotypes of different sites, and determining SNP site names, target genes, reference bases, mutant bases, phenotype information and medication suggestions corresponding to different phenotypes of the sample to be detected; and a report generation step: generating a report according to the genotype interpretation result, and outputting at least one group of SNP site names, target genes, reference bases, mutant bases, phenotype information and medication suggestions corresponding to different phenotypes of the sample to be detected. According to the application, an individualized medication suggestion report is obtained according to the PCR fluorescence signal of the sample to be detected, genetic evidence can be provided for clinically selecting proper drug types and drug doses, the period from sampling to issuing of a gene detection report is greatly shortened, and the diagnosis and treatment period of medical workers is further shortened.

Description

technical field [0001] The present application relates to the field of gene detection, in particular to a method, device and storage medium for gene detection of drug metabolizing enzymes and drug action targets. Background technique [0002] There are about 50 million hospitalized patients in my country every year, at least 2.5 million of which are related to adverse drug reactions. At present, the inefficiency of drugs is very high, and the main factor leading to adverse drug reactions and ineffectiveness is gene mutation. Pharmacogenomics has attracted global attention. For example, the U.S. Food and Drug Administration (FDA) issued drug-related genetic testing warnings for drugs such as clopidogrel, codeine, and valproic acid, and genetic testing should be performed before use; The Health and Family Planning Commission also issued the "Technical Guidelines for Drug Metabolizing Enzymes and Drug Target Gene Detection (Trial)". [0003] However, it takes at least a few da...

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Problems solved by technology

[0003] However, it takes at least a few days or even weeks for the existing common genetic testing methods from sampling to issuing a test report. During the waiting process, patients are likely to miss the best time window for treatment, or can only be treated according to traditional methods. Medical experience to test drugs first, failing to use the most suitable drug in combination with one's own genetic characteristics at the first time

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