Traditional Chinese medicine composition with effects of nourishing Yin, clearing heat, nourishing blood and calming nerves

A technology for nourishing blood, soothing the nerves, nourishing yin and clearing away heat, which can be used in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., and can solve problems such as inability to increase sleep depth, increase sleep depth of insomnia patients, and inability to obtain recovery effects.

Pending Publication Date: 2021-05-18
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] As mentioned above, insomnia seriously affects the physical and mental health and quality of life of patients, and also creates a heavy burden on society. Currently, commonly used sedative and hypnotic drugs can change sleep time, but cannot increase sleep depth and improve sleep quality. Therefore, it has the ability to regulate sleep structure. It is of great significance to develop new sedative-hypnotic drugs that can increase the depth of sleep in patients with insomnia and improve sleep quality.
[0007] Chemical drugs mostly play a therapeutic role on a single target, but insomnia is a complex chronic disease with multiple causes. It is difficult for chemical drugs to intervene in the disease as a whole, and cannot obtain a recovery effect close to that of physiological sleep, and has relatively large side effects

Method used

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  • Traditional Chinese medicine composition with effects of nourishing Yin, clearing heat, nourishing blood and calming nerves
  • Traditional Chinese medicine composition with effects of nourishing Yin, clearing heat, nourishing blood and calming nerves
  • Traditional Chinese medicine composition with effects of nourishing Yin, clearing heat, nourishing blood and calming nerves

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] Embodiment 1: the preparation of this Chinese medicine combination extract

[0097] The traditional Chinese medicine composition of the present invention is prepared from the following important raw materials in parts by weight: Danshen 10, Angelica 10, Shichangpu 10, Codonopsis 10, Poria cocos 10, Schisandra chinensis 10, Suanzaoren 10, Baiziren 10, Sunburn 100, Ophiopogon japonicus 10, Asparagus 10, Rehmannia glutinosa 10, Scrophulariaceae 10, Polygala 10, Campanulaceae 5, Licorice 5, Achyranthes bidentata 10, Eucommia 10, Pearl powder 1.

[0098] Add 10 times the amount and 70% ethanol to soak 9 medicinal herbs such as Salvia Miltiorrhiza, Angelica, Shichangpu, Codonopsis pilosula, Poria cocos, Schisandra chinensis, Jujube seed, Baiziren, and Sunburn in the weight ratio for 1 hour, heat, boil and reflux to extract 2 Filtrate for 1 hour and collect the filtrate. The dregs and the remaining 9 medicinal materials were combined and decocted twice. For the first time, 10...

Embodiment 2

[0100] Embodiment 2: the preparation of this traditional Chinese medicine combination extract hydrogel ointment

[0101]Pearl powder is added to the concentrated solution obtained in Example 1 to prepare the active ingredient of the medicament of the present invention. The active ingredients of the traditional Chinese medicine combination are added to the oil phase, sodium polyacrylate, aluminum hydroxide, kaolin, etc. are added in sequence to the glycerin and mixed well; water phase A: sodium carboxymethyl cellulose, PVP, etc. are added to the water, and dissolved for later use; Phase B: Take another small amount of water, add tartaric acid to dissolve; mix the oil phase and water phase A, add water phase B and mix thoroughly, apply on non-woven fabric, compound with release film, cut into specified Size, the hydrogel patch of the medicine is obtained, and each paste contains 10g of plaster and 1.7g of crude drug.

Embodiment 3

[0102] Example 3: Preparation of Tablets and Capsules

[0103] Add 0.2 kg of pearl powder to the concentrated solution obtained in Example 1, dry, pulverize into fine powder, add β-cyclodextrin inclusion compound and mix well. Put the above mixture of raw and auxiliary materials into a one-step granulator, add starch, lactose and microcrystalline cellulose (1:1:2) to granulate and dry. After determining that the moisture content is less than 2%, the granules are sieved with a 20-30 mesh, and 0.1-1% micronized silica gel and magnesium stearate are added and mixed evenly. Capsules are directly filled with 0# dark capsules (protected from light).

[0104] 8#-9# dies are used for tablet compression, and the tablet pressure is controlled at 20-40 Newton. The compressed tablet is placed in a coating machine, covered with moisture-proof and light-proof clothing, and the weight gain is controlled at 2%-4%. Capsules and tablets are packaged in aluminum-plastic-aluminum packaging mat...

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Abstract

The invention relates to a traditional Chinese medicine composition with the effects of nourishing Yin, clearing heat, nourishing blood and tranquilizing mind. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 5-15 parts of radix salviae miltiorrhizae, 5-15 parts of radix angelicae sinensis, 5-15 parts of rhizoma acori graminei, 5-15 parts of radix codonopsis, 5-15 parts of poria cocos, 5-15 parts of fructus schisandrae, 5-15 parts of semen ziziphi spinosae, 5-15 parts of semen platycladi, 5-15 parts of radix stemonae preparata, 5-15 parts of radix ophiopogonis, 5-15 parts of radix asparagi, 5-15 parts of radix rehmanniae preparata, 5-15 parts of radix scrophulariae, 5-15 parts of radix polygalae, 2.5-7.5 parts of radix platycodonis, 2.5-7.5 parts of radix glycyrrhizae, 5-15 parts of radix achyranthis bidentatae, 5-15 parts of cortex eucommiae and 0.5-1.5 parts of pearl powder.

Description

Technical field: [0001] The present invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition which has the function of regulating sleep and is suitable for insomnia, the traditional Chinese medicine "insomnia", "insomnia", "unsightly eyes" and "restless sleeping". Salvia, Angelica, Shichangpu, Codonopsis pilosula, Poria cocos, Schisandra chinensis, jujube seed, cypress kernel, sun-burned hundred leaves, Ophiopogon japonicus, asparagus, rehmannia glutinosa, scrophulariaceae, Polygala, bellflower, licorice, Achyranthes bidentata, Eucommia, pearl powder, etc. It is prepared as a traditional Chinese medicine raw material. [0002] technical background: [0003] Insomnia refers to a neuropsychiatric disease that occurs when sleep time is sufficient and the environment is suitable, and it is difficult to fall asleep or maintain sleep, which leads to daytime dysfunction. The main symptoms are difficulty falling asle...

Claims

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Application Information

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IPC IPC(8): A61K36/904A61P25/20A61K35/618
CPCA61K36/537A61K36/232A61K36/888A61K36/344A61K36/076A61K36/79A61K36/57A61K36/725A61K36/14A61K36/904A61K36/8968A61K36/8965A61K36/804A61K36/808A61K36/69A61K36/346A61K36/484A61K36/21A61K36/46A61K35/618A61P25/20A61K2236/333A61K2236/39A61K2236/331A61K2236/53A61K2236/51A61K2300/00
Inventor 张有志李劲草杜树山张杨薛瑞王洛萱李硕李迎董华进
Owner ACADEMY OF MILITARY MEDICAL SCI
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