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Construction method of prostatic cancer prognosis significant correlation ceRNA regulation and control network

A prostate cancer and regulatory network technology, applied in the field of medicine, can solve the problems of lack of regulatory network research, achieve precise regulation, and solve the effect of unbalanced sample size

Active Publication Date: 2021-05-25
NANJING UNIV OF POSTS & TELECOMM
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  • Abstract
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  • Application Information

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Problems solved by technology

However, studies on the mRNA-miRNA-lncRNA regulatory network related to cancer prognosis are still lacking.

Method used

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  • Construction method of prostatic cancer prognosis significant correlation ceRNA regulation and control network
  • Construction method of prostatic cancer prognosis significant correlation ceRNA regulation and control network
  • Construction method of prostatic cancer prognosis significant correlation ceRNA regulation and control network

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Embodiment Construction

[0042]The present invention will be further described below in conjunction with the accompanying drawings. The following examples are only used to illustrate the technical solution of the present invention more clearly, but not to limit the protection scope of the present invention.

[0043] Such as figure 1 As shown, it is a flowchart of a method for constructing a ceRNA regulatory network significantly related to the prognosis of prostate cancer in an embodiment of the present invention, including the following steps:

[0044] Step 1) Download the TCGA and GTEx prostate cancer normalized gene expression datasets from the UCSC database, and download the gene expression data, mRNA, miRNA expression data, lncRNA expression data and prostate cancer gene expression data in the TCGA (the cancergenome atlas) database. clinical information;

[0045] Step 2) Perform differential gene expression analysis on the prostate cancer normalized gene expression data of TCGA and GTEx databas...

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Abstract

The invention discloses a construction method of a prostatic cancer prognosis significant correlation ceRNA regulation network, which comprises the following steps: integrating prostatic cancer gene expression data sets of TCGA and GTEx databases, respectively carrying out differential gene expression analysis and weighted gene co-expression network analysis, and screening key module genes of differential expression; then acquiring the key gene is obtained through WGCNA analysis and Cox proportional risk regression analysis; subjecting the obtained key gene, miRNA and lncRNA to interaction relationship to construct the ceRNA network, and performing evaluation according to the expression trend of the lncRNA, miRNA and hub gene in PRAD. According to the invention, the survival analysis is combined to obtain the ceRNA regulation network significantly related to PRAD prognosis, such that the early diagnosis of the disease and the precise treatment of the targeted drug design can be conveniently performed.

Description

technical field [0001] The invention specifically relates to a method for constructing a ceRNA regulatory network significantly related to the prognosis of prostate cancer, and belongs to the field of medical technology. Background technique [0002] Prostate cancer is one of the most common malignant tumors in the male genitourinary system. In European and American countries, prostate cancer is the malignant tumor with the highest incidence rate in men, accounting for the third place in cancer mortality. From a global perspective, the incidence of prostate cancer in developed countries is higher than that in developing countries. At present, the United States, Britain, France, Germany and Japan account for 70% of the total number of patients. Although the incidence of prostate cancer in my country is lower than that in Europe and the United States, it has also shown an obvious upward trend in recent years with the rapid economic growth of the country. At present, prostate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B15/30G16H50/80
CPCG16B15/30G16H50/80Y02A90/10
Inventor 郭丽康一浩窦宇阳熊依琪颜小强夏道良
Owner NANJING UNIV OF POSTS & TELECOMM
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