Marker for predicting light-to-severe progression of COVID-19 patient, kit and establishment method

Abstract

The invention discloses a marker for rapidly predicting whether a COVID-19 patient suffers from light-to-severe progression or not, a kit thereof and an establishment method of the marker. According to the method, the severity of the condition of an early-stage COVID-19 patient is predicted through proteomics data, then potential critical patients are screened, and specific analysis can be carried out only by obtaining the three feature data of OAF, MB and DDT of the patient when the patient is admitted to hospital. The marker and the detection kit can timely, rapidly, objectively and accurately predict the severity of the condition of a COVID-19 patient and whether the disease progresses from light to severe, and assist medical staff in timely finding potential critical patients to allocate enough medical resources and attention, which are advantages that a traditional evaluation mode does not have. Therefore, the invention has great clinical application value for early rapid prediction and screening of the potential critical patients of COVID-19.

Description

technical field [0001] The invention belongs to the field of medical biotechnology, and in particular relates to a marker for rapidly predicting whether mild to severe progression occurs in COVID-19 patients, a kit and a method for establishing the same. Background technique [0002] Cases of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have increased dramatically worldwide. According to the Johns Hopkins University Coronavirus Resource Center website, as of June 8, 2020, 188 countries have reported more than 7 million cases and about 400,000 deaths. Studies have shown that approximately 80% of laboratory-confirmed patients have mild cases, which recover with or without conventional treatment. 20% are severe cases requiring intensive care, and 70% to 80% of these severe cases die within a few days. Therefore, preventing moderate-to-severe progression in patients with COVID-19 at the time of hospital admission ...

AI Technical Summary

Problems solved by technology

When mild to severe progression occurs rapidly, its predictive accuracy is very limited, unable to judge the severity of the patient's condition in time and predict whether the disease will worsen

Those COVID-19 patients without severe clinical manifestations and symptoms are often not correctly classified when they are admitted to the hospital so that they lose enough attention of medical staff, especially in the case of tight medical resources, medical staff cannot quickly progress to Make full preparations for treatment in the severe stage

Therefore, effective methods to screen patients with severe COVID-19 without severe symptoms are currently lacking but urgently needed

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