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Silver-loaded polyphosphazene microsphere with mesoporous core-shell structure as well as preparation method and application of silver-loaded polyphosphazene microsphere

A technology of core-shell structure and polyphosphazene, which is applied in the field of mesoporous core-shell structure polyphosphazene silver-loaded microspheres and its preparation, can solve problems such as agglomeration, prone to oxidative discoloration, and loss of nano-characteristics

Inactive Publication Date: 2021-05-28
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to overcome the problems that the traditional nano-silver antibacterial agent is prone to agglomeration and loses nano-characteristics, is difficult to uniformly disperse in organic materials, is prone to oxidative discoloration, and has biological toxicity, the present invention provides a medium with "long-acting antibacterial effect". Preparation method of polyphosphazene silver-loaded microspheres with pore core-shell structure

Method used

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  • Silver-loaded polyphosphazene microsphere with mesoporous core-shell structure as well as preparation method and application of silver-loaded polyphosphazene microsphere
  • Silver-loaded polyphosphazene microsphere with mesoporous core-shell structure as well as preparation method and application of silver-loaded polyphosphazene microsphere
  • Silver-loaded polyphosphazene microsphere with mesoporous core-shell structure as well as preparation method and application of silver-loaded polyphosphazene microsphere

Examples

Experimental program
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Effect test

Embodiment 1

[0041] (1) Configure 100mL 0.1M silver nitrate solution in a 250ml flask as a silver source, add the same mole of polyvinylpyrrolidone K30 and Tween 60 of three thousandths of the solution weight in turn, and stir vigorously for 0.5h under dark conditions until all raw materials All dissolved to form a homogeneous transparent solution; after heating to 30°C, add 5 mL of 0.1M sodium borohydride solution dropwise, after the addition is complete, stir in the dark for 30 minutes until the reaction is complete, and centrifuge the product at 6000r / min Separation, repeated alternate washing with ethanol and deionized water for 3 times, vacuum drying at 60°C for 24 hours to obtain hard template single-phase nano-silver particles;

[0042] (2) Take 0.04g of single-phase nano-silver particles and re-disperse them ultrasonically in 500mL of acetonitrile with an ultrasonic power of 300 watts and an ultrasonic frequency of 50 kHz, and add Tween 80 at 3 / 1000 of the solution weight to form a ...

Embodiment 2

[0051] (1) Configure 100mL 0.15M silver nitrate solution in a 250ml flask as a silver source, add the same mole of polyvinylpyrrolidone K30 and Tween 80 with a solution weight of 5‰, and stir vigorously for 0.5h under dark conditions until all raw materials are completely dissolved to form a homogeneous transparent solution; after heating to 90°C, add 5 mL of 0.15M sodium borohydride solution dropwise, and after the addition is complete, stir the reaction for 30 minutes in the dark until the reaction is complete, and centrifuge the product at 10,000 r / min. And use ethanol and deionized water to repeatedly alternately wash 3 times, and vacuum dry for 24 hours to obtain hard template single-phase nano-silver particles.

[0052] (2) Take 0.04g of single-phase nano-silver particles and re-disperse them in 500mL of acetonitrile with ultrasonic power of 300W and ultrasonic frequency of 50kHz, and add Tween 80 with a solution weight of 5‰, and form a stable suspension liquid after 1h ...

Embodiment 3

[0055] (1) Configure 100mL 0.05M silver nitrate solution in a 250ml flask as a silver source, add the same mole of polyvinylpyrrolidone K90 and sodium dodecylbenzenesulfonate with a solution weight of 3.5‰ in sequence, and stir vigorously for 0.5h under dark conditions Until all the raw materials are completely dissolved to form a uniform transparent solution; after heating to 60°C, add 5mL of 0.05M sodium borohydride solution dropwise, and after the addition is complete, stir the reaction in the dark for 30min until the reaction is completed, and the product is heated at 8000r / min centrifuged at a rotating speed, washed three times alternately with ethanol and deionized water, and vacuum-dried for 24 hours to obtain hard template single-phase nano-silver particles.

[0056] (2) Take 0.04g of single-phase nano-silver particles and re-disperse them ultrasonically in 500mL of tetrahydrofuran with an ultrasonic power of 300 watts and an ultrasonic frequency of 50 kHz, and add Twee...

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Abstract

The invention relates to the technical field of nano antibacterial materials, in particular to a silver-loaded polyphosphazene microsphere with a mesoporous core-shell structure and a preparation method and an application thereof. The preparation method comprises the following steps that 1, a protective agent and a dispersing agent are added into a silver nitrate solution and stirred to be uniform, heating is conducted to 30-90 DEG C, then a reducing agent is dropwise added, a reaction is conducted in a dark place, centrifugal separation is conducted, obtained sediment is washed with a washing agent, and drying is carried out in vacuum to obtain hard template single-phase nano silver particles; and (2) the hard template single-phase nano-silver particles are ultrasonically dispersed in an organic solvent, a dispersing agent, hexachlorocyclotriphosphazene and resveratrol are sequentially added, uniformly stirred, then an acid-binding agent is added, ultrasonic reaction and centrifugal separation are carried out, the obtained precipitate is washed with a detergent, and vacuum drying is carried out to obtain the silver-loaded polyphosphazene microsphere with the mesoporous core-shell structure. The prepared silver-loaded polyphosphazene microsphere with the mesoporous core-shell structure can achieve a long-acting sterilization effect, can improve the dispersibility of a nano material and reduce the biotoxicity of a silver-series antibacterial material, and can be applied as an antibacterial material.

Description

technical field [0001] The invention relates to the technical field of nanometer antibacterial materials, in particular to a polyphosphazene silver-loaded microsphere with a mesoporous core-shell structure and a preparation method and application thereof. Background technique [0002] As one of the most commonly used inorganic antibacterial agents, silver has the advantages of high efficiency, safety, and broad antibacterial spectrum. It has been widely used in industrial antibacterial products and has become a hot material in antibacterial scientific research. There are many kinds of silver-based antibacterial agents, including elemental silver, silver nanoparticles and silver-loaded antibacterial agents. - Activated carbon fiber type antibacterial agent, etc. [0003] In the past ten years, with the rapid development of nanomaterials and their preparation technology, the antibacterial ability of silver in the nano state has undergone a qualitative leap. Due to its small p...

Claims

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Application Information

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IPC IPC(8): A01N59/16A01N31/16A01N25/10A01N25/34A01P1/00C08G79/02B22F9/24B82Y40/00
CPCA01N59/16A01N31/16A01N25/10A01N25/34C08G79/025B22F9/24B82Y40/00
Inventor 沈思涛况太荣陈枫刘通钟明强
Owner ZHEJIANG UNIV OF TECH
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