Method for predicting anti-cancer efficacy of compound targeting apoptosis pathway and composition

A biomarker, cancer technology, applied in the field of cancer treatment
CN112852959APending Publication Date: 2021-05-28ASCENTAGE PHARMA SUZHOU CO LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ASCENTAGE PHARMA SUZHOU CO LTD
Publication Date
2021-05-28

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Abstract

The invention relates to a biomarker for predicting the efficacy of an MDM2 inhibitor or a Bcl-2 / Bcl-xL dual inhibitor or a Bcl-2 inhibitor or a Bcl-xL inhibitor in the treatment of a cancer patient. The invention also provides a composition, e.g. a kit, for assessing the gene levels of biomarkers, and a method for using such gene levels to predict the response of a cancer patient to the MDM2 inhibitor or the Bcl-2 / Bcl-xL dual inhibitor or the Bcl-2 inhibitor or the Bcl-xL inhibitor. The information can be used to determine prognosis and treatment selection for cancer patients.
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Description

technical field

[0001] The present invention relates generally to cancer treatment. Background technique

[0002] Evasion of apoptosis is a hallmark of human cancer and is a common cause of therapy resistance (Hanahan D et al, Cell [cell] (2000) 100:57-70; Delbridge AR et al, Cold Spring Harb Perspect Biol Perspectives in Biology] (2012) 4). Therefore, targeting key apoptotic players in human cancers is an attractive new strategy for the development of entirely new classes of anticancer therapies.

[0003] Clinical response to anticancer therapy is usually limited to a subset of patients. To maximize the efficiency of anticancer therapies, molecular biomarker-based personalized chemotherapy has been proposed. However, the identification of predictive biomarkers capable of predicting response to anticancer therapies remains a challenge. Therefore, there is a continuing need to develop biomarkers for predicting the anticancer efficacy of compounds targeting apoptotic pathw...

Claims

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