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Freeze-dried ball and preparation method thereof

A freeze-drying and polysaccharide technology, used in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve the problems of poor resolubility of freeze-dried balls, achieve excellent mechanical strength and toughness, high economic benefits, and solve the problem of resolubility. poor effect

Pending Publication Date: 2021-06-04
GUANGZHOU RIDGEPOLE BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Using collagen as the main component of the skeleton, on the one hand, does greatly improve the stability of the freeze-dried ball skeleton, but on the other hand, it causes the problem of poor resolubility of the freeze-dried ball

Method used

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  • Freeze-dried ball and preparation method thereof

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Effect test

preparation example Construction

[0052] A second aspect of the present invention provides a method for preparing freeze-dried balls, comprising the following steps:

[0053] S01: Dissolving polyols, polysaccharides, hyaluronate, and okra hydrolyzed glycoprotein in deionized water to form a solution;

[0054] S02: Pour the solution obtained in step S01 into the detachable upper and lower hemispherical molds, put the upper and lower molds with the solution in the freeze dryer, freeze at -45°C for 1-2 hours, and then remove the mold from the freeze dryer Take it out, put it at room temperature for 20-30 minutes, then separate the upper and lower molds, and freeze the solution into a sphere and place it in the lower mold;

[0055] S03: Put the lower mold with the sphere back into the freeze dryer, keep it warm at -45°C for 20-40 minutes, then raise the temperature to 5°C, control the vacuum at 10-30Pa, and dry for 10-20 hours; then raise the temperature again to 25°C, dry for 1-3 hours, then dry at 35-40°C, and ...

Embodiment 1

[0061] The invention relates to a freeze-dried ball. The raw materials for preparation include, in parts by weight, 2 parts of mannitol, 0.5 part of pullulan, 0.1 part of sodium hyaluronate, and 0.04 part of okra hydrolyzed glycoprotein.

[0062] The average molecular weight of okra hydrolyzed glycoprotein is 700000.

[0063] Okra hydrolyzed glycoprotein was purchased from Shanghai Jiayu Biotechnology Co., Ltd.; sodium hyaluronate was purchased from Bloomage Freda Biomedicine Co., Ltd.

[0064] A preparation method of freeze-dried balls, comprising the following steps:

[0065] S01: Dissolving mannitol, pullulan, sodium hyaluronate, and okra hydrolyzed glycoprotein in deionized water to form a solution;

[0066] S02: Pour the solution obtained in step S01 into the detachable upper and lower hemispherical molds, put the upper and lower molds containing the solution into a freeze dryer, freeze at -45°C for 2 hours, and then take the mold out of the freeze dryer, Place it at ro...

Embodiment 2

[0069] The invention relates to a freeze-dried ball. The raw materials are prepared in parts by weight, including: 4 parts of mannitol, 2 parts of pullulan, 0.3 part of sodium hyaluronate, and 0.1 part of okra hydrolyzed glycoprotein.

[0070] The average molecular weight of okra hydrolyzed glycoprotein is 700000.

[0071] Okra hydrolyzed glycoprotein was purchased from Shanghai Jiayu Biotechnology Co., Ltd.; sodium hyaluronate was purchased from Bloomage Freda Biomedicine Co., Ltd.

[0072] A preparation method of freeze-dried balls, comprising the following steps:

[0073] S01: Dissolving mannitol, pullulan, sodium hyaluronate, and okra hydrolyzed glycoprotein in deionized water to form a solution;

[0074] S02: Pour the solution obtained in step S01 into the detachable upper and lower hemispherical molds, put the upper and lower molds containing the solution into a freeze dryer, freeze at -45°C for 2 hours, and then take the mold out of the freeze dryer, Place it at room ...

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Abstract

The invention belongs to the technical field of cosmetics, and particularly relates to a freeze-dried ball and a preparation method thereof. The freeze-dried ball is prepared from the following raw materials in parts by weight: 1-8 parts of polyol, 0.1-5 parts of polysaccharide and 0.1-0.5 part of hyaluronate. The freeze-dried ball prepared by the preparation method can solve the problems of poor re-dissolvability, easy shrinkage due to moisture absorption and the like of a traditional freeze-dried ball due to the interaction among the polyol, the polysaccharide, the hyaluronate and the okra hydrolyzed glycoprotein. According to the freeze-dried ball prepared by the invention, a large amount of creative exploration, attempt and optimization are carried out on the preparation raw materials, so that the prepared freeze-dried ball is relatively low in cost to ensure relatively high economic benefits, and the application range of the freeze-dried ball is expanded.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and more specifically relates to a freeze-dried ball and a preparation method thereof. Background technique [0002] Traditionally packaged cosmetics often need to add preservatives in order to avoid microbial contamination during product storage, transportation and use. Studies have shown that preservatives are the most important allergens in cosmetics, and reducing the use of preservatives can greatly improve product safety. Using vial packaging, combined with freeze-drying process, cosmetics are presented in the form of freeze-dried powder, which can effectively guarantee the stability of active ingredients, and at the same time, the anhydrous condition is not conducive to the growth of microorganisms, avoiding the use of preservatives. [0003] Due to the remarkable efficacy and high safety of lyophilized powder in cosmetics, lyophilized powder products have been enthusiastically sought af...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/02A61K8/73A61K8/64A61K8/34A61Q19/00
CPCA61K8/735A61K8/345A61K8/73A61K8/645A61K8/025A61Q19/00A61K2800/84
Inventor 刘岸洪陈梓涛高合意曾飒
Owner GUANGZHOU RIDGEPOLE BIOLOGICAL TECH CO LTD
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