Preparation method of chitosan attapulgite membrane material having function of guiding bone tissue regeneration

A technology of bone tissue regeneration and attapulgite, applied in tissue regeneration, prosthesis, medical science, etc., can solve the problems of unfavorable cell migration and tissue formation, small pores of electrospun nanomaterials, and easy to produce immune rejection, etc. To achieve the effect of promoting the elimination of metabolites, good degradability, and promoting supply
CN112915262AActive Publication Date: 2021-06-08CHANGZHOU NO 2 PEOPLES HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHANGZHOU NO 2 PEOPLES HOSPITAL
Publication Date
2021-06-08

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Abstract

The invention provides a preparation method of a chitosan attapulgite membrane material having function of guiding bone tissue regeneration. The preparation method comprises the following preparation steps: dissolving chitosan in an acetic acid solution to obtain a chitosan acetic acid solution; adding attapulgite, and performing uniform mixing to obtain a chitosan / attapulgite mixed solution; putting the chitosan / attapulgite mixed solution in a container for film formation, then performing Gradient temperature cooling until freezing, and adding an ethanol / sodium hydroxide mixed solution for further freezing for several hours. and performing washing with a buffer solution, carrying out gradient alcohol dehydration, washing the membrane with a glycerol / aqueous solution, and performing natural drying at room temperature to obtain the chitosan attapulgite membrane material having the function of guiding bone tissue regeneration. The nanofiber membrane material prepared by the invention has good flexibility, degradability, biocompatibility and bone regeneration guiding function, has no toxic or side effect, and meets the requirements of tissue engineering materials.
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Description

technical field

[0001] The invention relates to the field of bone tissue regeneration and repair biomaterials, in particular to a preparation method of a chitosan attapulgite membrane material capable of guiding bone tissue regeneration. Background technique

[0002] There are more than 3 million patients with bone defects or dysfunction in my country every year. Bone injury or bone defect is very common clinically. At present, autologous bone or allogeneic bone transplantation is mainly used to promote bone regeneration and repair. Although the repairing effect of autologous bone grafting is obviously better than that of allograft bone grafting, autologous bone grafting has limited sources of materials and cannot meet clinical needs; although allograft bone sources are abundant, there are many shortcomings: ① prone to immune rejection; ② may carry heterogeneous bone source pathogens, there is a risk of zoonosis; ③ there are certain ethical issues. In order to overcome the...

Claims

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