Hernia repair material compounded with adipose-derived mesenchymal stem cells and gelatin sponge as well as preparation method and application of hernia repair material

A technology of gelatin sponge and stem cells, which is applied in the field of bioengineering, can solve the problems of poor strengthening strength, low survival rate of stem cells, and high cost, and achieve the effects of strengthening strength, improving survival rate, and delaying degradation speed
CN112957528AInactive Publication Date: 2021-06-15THE SECOND HOSPITAL OF SHANDONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE SECOND HOSPITAL OF SHANDONG UNIV
Publication Date
2021-06-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the technical field of bioengineering, in particular to a hernia repair material compounded with adipose-derived mesenchymal stem cells and gelatin sponge as well as a preparation method and application of the hernia repair material. The material comprises a biological patch and gelatin sponge on the lower side of the biological patch, and the gelatin sponge is filled with adipose-derived mesenchymal stem cells; the biological patch is of a natural fiber structure mainly composed of type I and type III collagen, and the number of adipose-derived mesenchymal stem cells in the gelatin sponge is 1 * 10 < 6 > to 3 * 10 < 6 > / cm < 2 >. After the gelatin sponge filled with the adipose-derived mesenchymal stem cells is compounded with the biological patch, the survival rate of the adipose-derived mesenchymal stem cells is increased, the degradation speed of the biological patch is delayed, wound healing is accelerated, muscle-like tissues are formed in vivo, the strength of the biological patch is enhanced, and the purpose of better treating abdominal wall soft tissue defect (hernia) is achieved.
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Description

technical field

[0001] The invention relates to the technical field of bioengineering, in particular to a hernia repair material composed of adipose-derived mesenchymal stem cells and gelatin sponge, a preparation method and application thereof. Background technique

[0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art.

[0003] The main component of biological mesh is collagen, which has become a hot spot in the research of hernia and abdominal wall surgery because of its good tissue compatibility, anti-infection, anti-adhesion, and complete degradation in vivo. Abdominal wall swelling and postoperative recurrence rate after application of bio-mesh are high, which is related to insufficient strength and rap...

Claims

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