Traditional Chinese medicine composition for resisting non-alcoholic fatty liver disease as well as preparation method and application of traditional Chinese medicine composition
A fatty liver disease and non-alcoholic technology, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., to block non-alcoholic fatty liver, prevent non-alcoholic fatty liver, and use less Effect
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Embodiment 1
[0035] According to the classical literature, the general dosage of Sanhuang Xiexin Decoction is Coptidis 6g, Scutellaria baicalensis 6-12g, and Dahuang 6g. In the embodiment, traditional Chinese medicines of different weights are mixed and decocted.
[0036] Table 1 Composition ratio of Sanhuang Xiexin Decoction
[0037] Proportion Coptidis (g) Scutellaria baicalensis (g) rhubarb (g) 1:1:1 6 6 6 1:2:1 6 12 6 1:1:2 6 6 12 2:1:1 12 6 6
[0038]The preparation method of the pharmaceutical composition is as follows: mix Coptis rhizome, Scutellaria baicalensis and rhubarb in different proportions according to Table 1, boil it into a paste, store it in the dark, and infuse it into the stomach after dilution.
Embodiment 2
[0039] Example 2: Comparison of Drug Curative Effects of Sanhuang Xiexin Decoction in Different Proportions in Treating Fatty Liver Mouse Model
[0040] High-fat-fed C57BL / 6J mice are commonly used non-alcoholic fatty liver mouse models, purchased from Shanghai Model Organisms Co., Ltd., and raised in an SPF environment for this experiment. In the experiment, 8-week-old male C57BL / 6J mice were selected and fed for 8 weeks to establish models, 10 mice in each group. After HE proved that the models were successfully established, they were administered orally for 4 weeks. Dosing frequency is 1 time / day, continuous treatment.
[0041] The following table shows the alanine aminotransferase (ALT) detected on an empty stomach after fasting for 12 hours in mice under the effect of different proportioning compositions; wherein, before treatment, it was the ALT that did not start treatment, and after treatment, it was the ALT after 4 weeks of administration. Alt.
[0042] The composit...
Embodiment 3
[0046] Example 3: Combination of different contents of Sanhuang Xiexin Decoction, the effect of treating fatty liver
[0047] As in Example 2 above, high-fat fed C57BL / 6J mice are commonly used non-alcoholic fatty liver mouse models, purchased from Shanghai Model Organisms Co., Ltd., and raised in an SPF environment for this experiment. In the experiment, 8-week-old male C57BL / 6J mice were selected and fed for 8 weeks to establish models, 10 mice in each group. After HE proved that the models were successfully established, they were administered orally for 4 weeks. Dosing frequency is 1 time / day, continuous treatment.
[0048] The following table shows the alanine aminotransferase (ALT) detected on an empty stomach after fasting for 12 hours in mice under the effect of different content compositions; wherein, before treatment, it is the ALT that has not started treatment, and after treatment, it is the ALT after 4 weeks of administration. .
[0049] The composition of table ...
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