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Dendrobium officinale polysaccharide/astragalus polysaccharide composite hydrogel as well as preparation method and application thereof

A technology of Dendrobium officinale polysaccharide and composite hydrogel, which is applied in the field of daily skin care products, can solve problems such as small composite gel preparations, no side effects are found, and achieve the effects of reducing cost, improving cardiovascular function and fast penetration

Pending Publication Date: 2021-06-25
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a compound gel preparation with good curative effect and small side effects has not been found on the market at present.

Method used

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  • Dendrobium officinale polysaccharide/astragalus polysaccharide composite hydrogel as well as preparation method and application thereof
  • Dendrobium officinale polysaccharide/astragalus polysaccharide composite hydrogel as well as preparation method and application thereof
  • Dendrobium officinale polysaccharide/astragalus polysaccharide composite hydrogel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A preparation method of dendrobium officinale polysaccharide / astragalus polysaccharide composite hydrogel, comprising the following steps:

[0041] 1) Weigh 0.5g Carbomer 980, 2.5g 1,2-propanediol, add part of purified water, stir and swell for 24 hours to obtain a blank gel matrix;

[0042] 2) Weigh 0.5 g of ball-milled Dendrobium officinale polysaccharide and Astragalus polysaccharide composite powder, dissolve it in purified water, stir evenly, add to the blank gel matrix obtained in step 1), and stir evenly;

[0043] 3) Weigh 2.5g of diethylene glycol monoethyl ether, 50mg of methylparaben, 0.5g of vitamin C and 0.5g of vitamin E, and add them to the mixed solution obtained in step 2), then adjust with 1% sodium hydroxide solution The pH was about 5.0, and the remaining purified water was added to a total weight of 50 g, and mixed evenly to obtain the Dendrobium officinale polysaccharide / Astragalus polysaccharide composite hydrogel, which was set aside.

Embodiment 2

[0045] A preparation method of dendrobium officinale polysaccharide / astragalus polysaccharide composite hydrogel, comprising the following steps:

[0046] 1) Weigh 0.5g Carbomer 980, 2.5g 1,2-propanediol, add part of purified water, stir and swell for 24 hours to obtain a blank gel matrix;

[0047] 2) Weigh 0.5 g of the ball-milled composite powder of Dendrobium officinale polysaccharide and Astragalus polysaccharide, dissolve it in purified water, stir evenly, add to the blank gel matrix obtained in step 1), and stir evenly;

[0048] 3) Weigh 5g of diethylene glycol monoethyl ether, 75mg of methylparaben, 0.5g of vitamin C and 0.5g of vitamin E, and add them to the mixed solution obtained in step 2), and then adjust them with 1% sodium hydroxide solution When the pH is 5.5, add the remaining purified water to a total weight of 50 g, and mix well to obtain the Dendrobium candidum polysaccharide / Astragalus polysaccharide composite hydrogel for future use.

Embodiment 3

[0050] A preparation method of dendrobium officinale polysaccharide / astragalus polysaccharide composite hydrogel, comprising the following steps:

[0051] 1) Weigh 0.5g Carbomer 980, 2.6g 1,2-propanediol, add part of purified water, stir and swell for 24 hours to obtain a blank gel matrix;

[0052] 2) Weigh 0.5 g of the ball-milled composite powder of Dendrobium officinale polysaccharide and Astragalus polysaccharide, dissolve it in purified water, stir evenly, add to the blank gel matrix obtained in step 1), and stir evenly;

[0053] 3) Weigh 7.5g of diethylene glycol monoethyl ether, 50mg of methylparaben, 0.5g of vitamin C and 0.5g of vitamin E, and add them to the mixed solution obtained in step 2), and then adjust the pH with 1% sodium hydroxide 6, add the remaining purified water to a total weight of 50g, and mix well to obtain the Dendrobium officinale polysaccharide / Astragalus polysaccharide composite hydrogel for future use.

[0054] Comparing Examples 1-3, it can be...

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Abstract

The invention discloses dendrobium officinale polysaccharide / astragalus polysaccharide composite hydrogel as well as a preparation method and application thereof. The preparation prescription of the dendrobium officinale polysaccharide / astragalus polysaccharide composite hydrogel takes composite polysaccharide of dendrobium officinale polysaccharide and astragalus polysaccharide as a main medicine. The preparation comprises the following components in percentage by mass: 1%-2% of the main medicine, 0.5%-1.8% of a gel matrix, 5%-15% of a skin penetration promoting agent, 5%-10% of a humectant, 1%-5% of an antioxidant, 0.1%-0.2% of a preservative and the balance of water, and the pH value of the solution is regulated by a pH regulator. According to the composite hydrogel disclosed by the invention, polysaccharide extracted from natural plants dendrobium officinale and astragalus membranaceus is utilized, an anti-inflammatory and anti-aging skin care product external preparation is researched, and pharmacological experiments prove that the product disclosed by the invention has the curative effects of resisting bacteria, diminishing inflammation, whitening, moisturizing, resisting aging, nourishing skin and the like. A ball milling method is adopted to assist extraction, effective active ingredients of dendrobium officinale are reserved to the maximum extent, the cost is reduced, the method is easy to operate, and industrial production is easy to achieve.

Description

technical field [0001] The invention relates to the technical field of daily skin care products, in particular to a dendrobium officinale polysaccharide / astragalus polysaccharide composite hydrogel and a preparation method and application thereof. Background technique [0002] Dendrobium officinale (Dendrobium officinale) is derived from a variety of plants of the genus Dendrobium, which is one of the largest genus of Orchidaceae, and is widely distributed in tropical and subtropical regions of Asia. my country is mainly produced in Sichuan, Guizhou, Yunnan and the Yangtze River Basin. Dendrobium officinale is a precious medicinal material in traditional Chinese medicine. It has the functions of nourishing the stomach and promoting body fluid, nourishing the liver and improving eyesight, nourishing the kidney and moistening the lung, and strengthening the body. Studies have shown that polysaccharides are an important component of Dendrobium officinale, and polysaccharides i...

Claims

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Application Information

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IPC IPC(8): A61K8/04A61K8/67A61K8/73A61K9/06A61K31/715A61K47/22A61P17/00A61P29/00A61Q19/00A61Q19/08A61K31/375A61K31/355
CPCA61K8/042A61K8/73A61K31/715A61K9/06A61K47/22A61P29/00A61P17/00A61Q19/00A61Q19/08A61K31/355A61K31/375A61K8/678A61K8/676A61K2800/5922A61K2800/805A61K2236/15
Inventor 陈雪帆许配玉
Owner ZHEJIANG UNIV OF TECH
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