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Micro-nano robot and preparation method and application thereof

A robot, micro-nano technology, applied in the field of micro-nano robots, can solve problems such as lack of versatility, inability to obtain modular robots, and rising robot resistance.

Active Publication Date: 2021-06-25
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

(5) As the input frequency gradually increases (>56 Hz), the resistance on the robot rises and eventually exceeds the magnetic interaction force between the two robots, causing the robot to disintegrate (such as Figure 3a to Figure 3d ) shown
Although the robot system in the above literature can dynamically reconfigure the size and shape, the maximum assembly quantity of the modular robot is 3, and the versatility is insufficient, and the ideal modular robot cannot be obtained

Method used

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  • Micro-nano robot and preparation method and application thereof
  • Micro-nano robot and preparation method and application thereof

Examples

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Embodiment 1

[0058] This embodiment provides a micro-nano robot, the preparation method of which is as follows:

[0059] Amino modification (NH 2 -Fe 3 o 4 ) magnetic microbeads (100 μL, 4.18 μm, 2.5 g / mL) in a monodisperse aqueous solution were added biotin (biotin, 100 μg), 4,4'-azooxy (4-cyanovaleric acid) (0.1 g), N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC, 0.035g) and N-hydroxybutanediimine (NHS, 0.028g), at a temperature of 25°C Shake for 24 hours, then add NH 2 -Fe 3 o 4 The same number of streptavidin-modified magnetic microspheres (SA-Fe 3 o 4 , 4.18 μm,), washed with water three times, and freeze-dried to obtain the micro-nano robot.

[0060] The scanning electron microscope image of the micro-nano robot prepared in this example is as follows: Figure 4 As shown in the figure, the assembly number of the obtained micro-nano robot is 3.

Embodiment 2

[0062] This embodiment provides a micro-nano robot, the preparation method of which is as follows:

[0063] Amino modification (NH 2 -Fe 3 o 4 ) magnetic microbeads (100μL, 4.18μm, 2.5g / mL) in monodisperse aqueous solution, add 4,4'-azooxy (4-cyanovaleric acid) (0.1g), N-(3-dimethyl Aminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC, 0.035g) and N-hydroxybutanediimine (NHS, 0.028g), shaking at 25°C for 24h, washing with water three times, freeze-drying to obtain the micro-nano robot.

[0064] The scanning electron microscope image of the micro-nano robot prepared in this example is as follows: Figure 5 As shown in the figure, there are different assembly numbers of micro-nano robots, because the assembly of magnetic micro-beads mainly relies on magnetic beads and AZO molecules in the form of a functional group, and the probability of assembling more than 3 is reduced, which is mainly assembled by 2 robots. form.

Embodiment 3

[0066] This embodiment provides a micro-nano robot, the preparation method of which is as follows:

[0067] Amino modification (NH 2 -Fe 3 o 4 ) magnetic microbeads (100 μL, 4.18 μm, 2 g / mL) in a monodisperse aqueous solution were added biotin (biotin, 100 μg), 4,4'-azooxy (4-cyanovaleric acid) (0.1 g), N -(3-Dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC, 0.035g) and N-hydroxybutanediimine (NHS, 0.028g), then added with NH 2 -Fe 3 o 4 The same number of streptavidin-modified magnetic microspheres (SA-Fe 3 o 4 , 4.18 μm,), shaking at 20° C. for 30 h, washing with water three times, and freeze-drying to obtain the micro-nano robot.

[0068] The scanning electron microscope image of the micro-nano robot prepared in this example is as follows: Figure 6a with 6b As shown in the figure, the assembly number of micro-nano robots is 3.

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Abstract

The invention relates to a micro-nano robot and a preparation method and application thereof. The preparation method comprises the following steps: mixing amino-modified magnetic microbead dispersion liquid with 4,4- azoxy(4-cyanovaleric acid) for amidation to obtain the micro-nano robot. According to the invention, 4,4- azoxy(4-cyanovaleric acid) and amino groups on the magnetic microbeads form stable covalent bonds, so that the number of assembled modules is adjustable. Meanwhile, due to the introduction of 4,4-azoxy(4-cyanovaleric acid), the micro-nano robot can have the advantage of releasing drugs in a near-infrared light response manner. The micro-nano robot has modification performance, and various drugs such as anti-cancer drug adriamycin can be connected to the tail ends of the magnetic microbeads in the micro-nano robot for near-infrared response targeted therapy of tumors. In addition, the micro-nano robot can be adapted to application in different environments.

Description

technical field [0001] The invention relates to the technical field of micro-nano robots, in particular to a micro-nano robot and its preparation method and application. Background technique [0002] Magnetically controlled micro / nanorobots have been extensively studied due to their ability to enhance the targeting capabilities of micro / nanosystems, such as drug delivery systems. Micro / nano-robots are used in a wide range of fields, including environmental, biomedical applications (including cell transplantation, tumor-targeted drug delivery, and minimally invasive surgery). At present, micro-nano robots have been proved to have excellent ability to move or work in a homogeneous environment and complete a single specific task, however, they are faced with complex tissue structures and environments in vivo, such as blood circulation, diffusion of tumor microenvironment and biological barriers. Such as extracellular matrix, robots with a single shape and function can no longe...

Claims

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Application Information

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IPC IPC(8): B25J11/00
CPCB25J11/00
Inventor 郑裕基宋小霞
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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