Method for preparing nicotinamide-coated multivesicular liposomes

A technology of nicotinamide and liposomes, which is applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as the poor quality of nicotinamide, achieve good stability, improve application versatility, The effect of simple preparation process

Inactive Publication Date: 2017-05-10
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the above-mentioned technical problems in the prior art, the present invention provides a multivesicular liposome coated with nicotinamide and a preparation method thereof, the multivesicular liposome coated with nicotinamide and its preparation method The preparation method should solve the technical problem of poor quality of nicotinamide in the prior art

Method used

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  • Method for preparing nicotinamide-coated multivesicular liposomes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] A multivesicular liposome coated with nicotinamide, calculated by weight percentage, its raw material composition and content are as follows:

[0087] Phospholipids 1.0%;

[0088] Neutral Lipid 1.0%;

[0089] Cholesterol 1.0%;

[0090] Organic solvent 5.0%;

[0091] Niacinamide 0.01%;

[0092] Hydrophilic emulsifier 0.1%;

[0093] Amino acid 0.1%;

[0094] Osmotic pressure regulator 2.0%;

[0095] Deionized water balance;

[0096] Described phospholipid is lecithin;

[0097] Described neutral fat is glyceryl trioleate;

[0098] Described organic solvent is ether;

[0099] Described hydrophilic emulsifier is Tween 80;

[0100] Described amino acid is lysine;

[0101] The osmotic pressure regulator is glucose;

[0102] The above-mentioned preparation method of multivesicular liposomes coated with nicotinamide specifically comprises the following steps:

[0103] 1) Weighing phospholipids, neutral lipids, cholesterol, organic solvents, hydrophilic emulsifiers, ...

Embodiment 2

[0111] A multivesicular liposome coated with nicotinamide, calculated by weight percentage, its raw material composition and content are as follows:

[0112] Phospholipids 10.0%;

[0113] Neutral lipid 5.0%;

[0114] Cholesterol 5.0%;

[0115] Organic solvent 12.5%;

[0116] Niacinamide 2.5%;

[0117] Hydrophilic emulsifier 6.0%;

[0118] Amino acid 0.5%;

[0119] Osmotic pressure regulator 5.0%;

[0120] Deionized water balance;

[0121] The phospholipid is one or a mixture of hydrogenated lecithin and soybean lecithin;

[0122] Described neutral substance is glyceric acid;

[0123] Described organic solvent is ethanol;

[0124] The hydrophilic emulsifier is one or a mixture of polyoxyethylene-polyoxypropylene block copolymer and PEG-100 stearate;

[0125] The amino acid is aspartic acid;

[0126] The osmotic pressure regulator is sucrose;

[0127] The above-mentioned preparation method of multivesicular liposomes coated with nicotinamide specifically comprises th...

Embodiment 3

[0136] A multivesicular liposome coated with nicotinamide, calculated by weight percentage, its raw material composition and content are as follows:

[0137] Phospholipids 20.0%;

[0138] Neutral Lipid 10.0%;

[0139] Cholesterol 10.0%;

[0140] Organic solvent 20.0%;

[0141] Niacinamide 5.0%;

[0142] Hydrophilic emulsifier 12.0%;

[0143] Amino acid 1.0%;

[0144] Osmotic pressure regulator 8.0%;

[0145]Deionized water 14.0%;

[0146] Described phosphoric acid is phosphatidylethanolamine;

[0147] The neutral lipid is one or a mixture of tricaprylin and vitamin E;

[0148] Described organic solvent is butanol;

[0149] The hydrophilic emulsifier is one or a mixture of peptide bimolecular lipophilic and hydrophilic surfactants, cetearyl alcohol and cetearyl glucoside;

[0150] The amino acid is L-arginine;

[0151] Described osmotic pressure regulator is physiological saline;

[0152] The above-mentioned preparation method of multivesicular liposomes coated with...

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Abstract

The invention relates to a method for preparing nicotinamide-coated multivesicular liposomes. The nicotinamide-coated multivesicular liposomes are prepared from phospholipid, neutral lipid, cholesterol, an organic solvent, a hydrophilic emulsifier, nicotinamide, amino acid, an osmotic pressure regulator and deionized water. The method comprises the steps: dissolving the phospholipid, the cholesterol and the neutral lipid in the organic solvent, so as to obtain an organic phase; uniformly mixing the nicotinamide, the amino acid, the osmotic pressure regulator and the deionized water, so as to obtain an internal water phase; homogenizing the organic phase component, and adding the internal water phase component into the organic phase component, so as to prepare a W/O primary emulsion; mixing the hydrophilic emulsifier, the amino acid, the osmotic pressure regulator and the deionized water, and carrying out dispersing, so as to obtain an external water phase; homogenizing the external water phase component, adding the W/O primary emulsion component into the external water phase component, carrying out homogenizing, then, carrying out ultrasonic treatment, and then, cooling the mixture to room temperature with stirring, so as to form a W/O/W multiple emulsion; dispersing the multiple emulsion into an amino acid solution, introducing nitrogen gas into the solution to remove the organic solvent, thereby obtaining a nicotinamide-coated multivesicular liposome suspension. According to the method, the stability of the nicotinamide is improved.

Description

technical field [0001] The invention belongs to the field of cosmetics and relates to a liposome, in particular to a multivesicle liposome coated with nicotinamide and a preparation method thereof. Background technique [0002] Niacinamide, a derivative of vitamin B3, is a multifunctional active substance that has attracted more and more attention in recent years. It has 6 major skin care effects: whitening, anti-aging, improving skin barrier function, moisturizing, oil control and Shrink pores, treat acne. Therefore, its application in cosmetics involves whitening products, anti-wrinkle products, moisturizing products, anti-acne products, and hair care products. However, nicotinamide is very sensitive to pH and has poor stability. In a solution with a pH value higher or lower than 6, it will be hydrolyzed to form nicotinic acid, causing skin allergies; Caking and poor stability during storage, thus limiting the widespread use of niacinamide in cosmetics. [0003] Multive...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/67A61K8/55A61K8/63A61K8/44A61Q19/00
CPCA61K8/14A61K8/44A61K8/553A61K8/63A61K8/675A61K2800/10A61K2800/412A61Q19/00
Inventor 张婉萍李玲玉欧文华朱海洋
Owner SHANGHAI INST OF TECH
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