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Water-soluble glabridin-coated multivesicular lipidosome and preparation method thereof

A glabridin, water-soluble technology, applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve problems such as poor stability of water-soluble glabridin, achieve good stability, and promote penetration. Sex, enhance the effect of activity

Inactive Publication Date: 2017-05-31
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Aiming at the above-mentioned technical problems in the prior art, the present invention provides a multivesicular liposome coated with water-soluble glabridin and a preparation method thereof, the multivesicular liposome coated with water-soluble glabridin Bubble liposome and preparation method thereof shall solve the technical problem of poor stability of water-soluble glabridin in the prior art

Method used

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  • Water-soluble glabridin-coated multivesicular lipidosome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] A multivesicular liposome coated with water-soluble glabridin, calculated by weight percentage, its raw material composition and content are as follows:

[0087] Phospholipids 1.0%;

[0088] Neutral Lipid 1.0%;

[0089] Cholesterol 1.0%;

[0090] Organic solvent 5.0%;

[0091] Water-soluble Glabridin 0.01%;

[0092] Hydrophilic emulsifier 0.1%;

[0093] Amino acid 0.1%;

[0094] Osmotic pressure regulator 2.0%;

[0095] Deionized water balance; %

[0096] Described phospholipid is lecithin;

[0097] Described neutral fat is glyceryl trioleate;

[0098] Described organic solvent is ether;

[0099] Described hydrophilic emulsifier is Tween 80;

[0100] Described amino acid is lysine;

[0101] The osmotic pressure regulator is glucose;

[0102] The above-mentioned preparation method of multivesicular liposomes coated with water-soluble glabridin specifically comprises the following steps:

[0103] 1) Weighing phospholipids, neutral lipids, cholesterol, organic...

Embodiment 2

[0111] A multivesicular liposome coated with water-soluble glabridin, calculated by weight percentage, its raw material composition and content are as follows:

[0112] Phospholipids 10.0%;

[0113] Neutral lipid 5.0%;

[0114] Cholesterol 5.0%;

[0115] Organic solvent 12.5%;

[0116] Water-soluble Glabridin 2.5%;

[0117] Hydrophilic emulsifier 6.0%;

[0118] Amino acid 0.5%;

[0119] Osmotic pressure regulator 5.0%;

[0120] Deionized water 53.5%;

[0121] The phospholipid is one or a mixture of hydrogenated lecithin and soybean lecithin;

[0122] Described neutral substance is glyceric acid;

[0123] Described organic solvent is ethanol;

[0124] The hydrophilic emulsifier is one or a mixture of polyoxyethylene-polyoxypropylene block copolymer and PEG-100 stearate;

[0125] The amino acid is aspartic acid;

[0126] The osmotic pressure regulator is sucrose;

[0127] The above-mentioned preparation method of multivesicular liposomes coated with water-soluble gla...

Embodiment 3

[0136] A multivesicular liposome coated with water-soluble glabridin, calculated by weight percentage, its raw material composition and content are as follows:

[0137]Phospholipids 20.0%;

[0138] Neutral Lipid 10.0%;

[0139] Cholesterol 10.0%;

[0140] Organic solvent 20.0%

[0141] Water-soluble Glabridin 5.0%;

[0142] Hydrophilic emulsifier 12.0%;

[0143] Amino acid 1.0%;

[0144] Osmotic pressure regulator 8.0%;

[0145] Deionized water 14.0%;

[0146] Described phosphoric acid is phosphatidylethanolamine;

[0147] The neutral lipid is one or a mixture of tricaprylin and vitamin E;

[0148] Described organic solvent is butanol;

[0149] The hydrophilic emulsifier is one or a mixture of peptide bimolecular lipophilic and hydrophilic surfactants, cetearyl alcohol and cetearyl glucoside;

[0150] The amino acid is L-arginine;

[0151] Described osmotic pressure regulator is physiological saline;

[0152] The above-mentioned preparation method of multivesicular...

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Abstract

The invention discloses a water-soluble glabridin-coated multivesicular lipidosome which is prepared from phospholipid, neutral lipid, cholesterol, an organic solvent, a hydrophilic emulsifier, water-soluble glabridin, amino acid, an osmotic pressure regulator and deionized water. The phospholipid, the cholesterol and the neutral lipid are dissolved into the organic solvent to be used as an organic phase; the water-soluble glabridin, amino acid, the osmotic pressure regulator and the deionized water are mixed as an inner water phase; organic phase components are added to inner water phase components to prepare W / O-type primary emulsion; the hydrophilic emulsifier, amino acid, the osmotic pressure regulator and the deionized water are mixed as an outer water phase; outer water phase components are homogenized, the W / O-type primary emulsion is added and the mixture is homogenized and subjected to ultrasonic treatment to be stirred and cooled so as to form W / O / W-type multi-emulsion; and the multi-emulsion is dispersed into an amino acid solution and nitrogen is introduced to remove the organic solvent to obtain a water-soluble glabridin-coated multivesicular lipidosome suspension. The stability of the water-soluble glabridin is improved.

Description

technical field [0001] The invention belongs to the field of cosmetics and relates to a liposome, in particular to a multivesicle liposome coated with water-soluble glabridin and a preparation method thereof. Background technique [0002] Glabridin is a natural high-efficiency whitening factor. Its whitening effect is 232 times higher than that of vitamin C, a common ingredient. It is known as "whitening gold". It has strong antibacterial, anti-oxidation, and prevents inflammation and pigmentation caused by ultraviolet rays. It can cooperate with the skin's self-repair process, enhance the whitening effect, and deeply moisturize the skin after sun exposure. The application of glabridin in cosmetics mainly has three aspects: whitening and inhibiting melanogen; anti-inflammation; anti-oxidation. Due to the water-insoluble nature of glabridin, it is generally modified to be water-soluble to expand the scope of application. However, water-soluble glabridin has poor stability in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/44A61K8/49A61K8/55A61K8/63A61Q19/00
CPCA61K8/14A61K8/44A61K8/498A61K8/553A61K8/63A61K2800/10A61K2800/412A61Q19/00
Inventor 张婉萍李玲玉张倩洁朱海洋
Owner SHANGHAI INST OF TECH
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